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The Mitogen-Activated Protein Kinase Pathway for Molecular-Targeted Cancer Treatment

  • Judith S. Sebolt-Leopold
  • Roman Herrera
  • Jeffrey F. Ohren
Part of the Resent Results in Cancer Research book series (RECENTCANCER, volume 172)

Abstract

The molecular characterization of key events associated with tumor initiation and progression has led to the identification of cellular signaling pathways that contribute not only to normal cell functioning but also to the overall phenotype associated with cancer. One such example is the Ras-regulated kinase pathway. This signaling module, comprising Raf, mitogen-activated protein kinase kinase (MEK), and extracellular signal-regulated kinase (ERK), plays a central role in regulating a broad range of cellular events. In response to a diverse group of extracellular stimuli including growth factors, cytokines, and protooncogenes, activation of this pathway results in alterations in cell proliferation, differentiation, and survival. It is therefore not surprising that this pathway has been found to be upregulated in a large percentage of human tumors. While contributing to the uncontrolled growth and enhanced survival of tumor cells, the Ras-MAP kinase pathway also plays a key role in their metastatic spread by regulating cell motility and invasion.

Keywords

Papillary Thyroid Carcinoma BRAF Mutation Conserve Phosphorylation Site Kinase Domain Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Judith S. Sebolt-Leopold
    • 1
  • Roman Herrera
    • 1
  • Jeffrey F. Ohren
    • 1
  1. 1.Pfizer Global Research and DevelopmentMichigan LaboratoriesAnn ArborUSA

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