The Genome Halving Problem is motivated by the whole genome duplication events in molecular evolution that double the gene content of a genome and result in a perfect duplicated genome thatcontains two identical copies of each chromosome. The genome then becomes a subject to rearrangements resulting in some rearranged duplicated genome. The Genome Halving Problem (first introduced and solved by Nadia El-Mabrouk and David Sankoff) is to reconstruct the ancestral pre-duplicated genome from the rearranged duplicated genome. The El-Mabrouk–Sankoff algorithm is rather complex and in this paper we present a simpler algorithm that is based on a generalization of the notion of the breakpoint graph to the case of duplicated genomes. This generalization makes the El-Mabrouk–Sankoff result more transparent and promises to be useful in future studies of genome duplications.


Genome Duplication Genome Duplication Event Cycle Decomposition Signed Permutation Black Edge 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Max A. Alekseyev
    • 1
  • Pavel A. Pevzner
    • 1
  1. 1.Department of Computer Science and EngineeringUniversity of California at San DiegoLa JollaU.S.A.

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