Determining Malignancy of Brain Tumors by Analysis of Vessel Shape

  • Elizabeth Bullitt
  • Inkyung Jung
  • Keith Muller
  • Guido Gerig
  • Stephen Aylward
  • Sarang Joshi
  • Keith Smith
  • Weili Lin
  • Matthew Ewend
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3217)


Vessels supplying malignant tumors are abnormally shaped. This paper describes a blinded study that assessed tumor malignancy by analyzing vessel shape within MR images of 21 brain tumors prior to surgical resection. The program’s assessment of malignancy was then compared to the final histological diagnosis. All tumors were classified correctly as benign or malignant. Of importance, malignancy-associated vessel abnormalities extend outside apparent tumor margins, thus allowing classification of even small or hemorrhagic tumors.


Brain Tumor Total Path Length Vessel Analysis Magnetic Resonance Unit Vessel Tortuosity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Elizabeth Bullitt
    • 1
  • Inkyung Jung
    • 2
  • Keith Muller
    • 2
  • Guido Gerig
    • 3
  • Stephen Aylward
    • 4
  • Sarang Joshi
    • 5
  • Keith Smith
    • 4
  • Weili Lin
    • 4
  • Matthew Ewend
    • 1
  1. 1.Department of SurgeryUniversity of North CarolinaChapel HillUSA
  2. 2.Department of BiostatiscsUniversity of North CarolinaChapel HillUSA
  3. 3.Department of Computer ScienceUniversity of North CarolinaChapel HillUSA
  4. 4.Department of RadiologyUniversity of North CarolinaChapel HillUSA
  5. 5.Department of Radiation OncologyUniversity of North CarolinaChapel HillUSA

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