Extracting Biochemical Reaction Kinetics from Time Series Data

  • Edmund J. Crampin
  • Patrick E. McSharry
  • Santiago Schnell
Part of the Lecture Notes in Computer Science book series (LNCS, volume 3214)


We consider the problem of inferring kinetic mechanisms for biochemical reactions from time series data. Using a priori knowledge about the structure of chemical reaction kinetics we develop global nonlinear models which use elementary reactions as a basis set, and discuss model construction using top-down and bottom-up approaches.


Basis Function Time Series Data Elementary Reaction Model Size Bimolecular Reaction 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Edmund J. Crampin
    • 1
  • Patrick E. McSharry
    • 2
    • 3
  • Santiago Schnell
    • 4
    • 5
  1. 1.Bioengineering InstituteThe University of AucklandAucklandNew Zealand
  2. 2.Mathematical InstituteOxfordUK
  3. 3.Department of Engineering ScienceUniversity of OxfordOxfordUK
  4. 4.Centre for Mathematical BiologyMathematical InstituteOxfordUK
  5. 5.Christ ChurchOxfordUK

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