The effects of diaphragm rupture and particle loading in contoured shock tubes for vaccine delivery
Biological Ballistics, or “Biolistics”, is a method by which micro-particle formulations of vaccine can be delivered to human skin or mucosa. A particle acceleration device, the Contoured Shock Tube (CST), has recently been described and characterised experimentally and numerically [2,3,6]. Essentially, the CST comprises a shock tube coupled to a correctly expanded nozzle. The particles are initially retained on a thin diaphragm while the upstream driver section is pressurised with air or helium. Rupture of the diaphragm initiates a classic shock tube flow through the device and consequent nozzle starting process. The design principle of the CST is that the particles be entrained within a quasi-steady, supersonic flow window which is bounded downstream by the nozzle starting process and upstream by the expansion reflected from the driver endwall.
KeywordsComputational Fluid Dynamics Particle Image Velocimetry Shock Tube Particle Cloud Pressure History
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