Modeling Subtilin Production in Bacillus subtilis Using Stochastic Hybrid Systems

  • Jianghai Hu
  • Wei-Chung Wu
  • Shankar Sastry
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2993)


The genetic network regulating the biosynthesis of subtilin in Bacillus subtilis is modeled as a stochastic hybrid system. The continuous state of the hybrid system is the concentrations of subtilin and various regulating proteins, whose productions are controlled by switches in the genetic network that are in turn modeled as Markov chains. Some preliminary results are given by both analysis and simulations.


Markov Chain Bacillus Subtilis Hybrid System Continuous State Equilibrium Distribution 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Jianghai Hu
    • 1
  • Wei-Chung Wu
    • 1
  • Shankar Sastry
    • 1
  1. 1.Department of Electrical Engineering and Computer SciencesUniversity of California at BerkeleyBerkeleyUSA

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