Determining Elementary Modes of Functioning in Biochemical Reaction Networks at Steady State
In the modelling of biochemical reaction systems, analysis of steady states plays an important role, because virtually stationary regimes are frequently encountered in experimental settings and under in-vivo conditions. Since in steady states, all intermediates have to be balanced with respect to inputs and outputs, the vector, V, of stationary reaction rates (called fluxes below) has to be situated in the null-space (kernel)of the stoichiometry matrix, N (cf. Clarke, 1980, 1988; Thomas and Fell, 1993).
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