Experimental Basis for Optimal Regimnes of Hyperthermic Peritoneal Chemotherapy

  • Natalia Yu. Anisimova
  • Irina Zh. Zhubina
  • Fedor V. Donenko
  • Julia I. Dolzhikova
  • Antonina V. Kshnaykina
  • Mikhail V. Kiselevskiy


Temperature exposure reliably inhibits tumor cell potential for proliferation at the temperature of not less than 43 °C only. Temperature regimens recommended for clinical treatment (40–42 °С) have no significant impact on the viability of tumor cells. Tumor growth arrest in murine models was observed only in case of preliminary warming of inoculated cells at a temperature more than 42 °С. Heating tumor cells up to 39 °С and their incubation with anticancer drugs in the mean-effective concentrations enhanced tumor cell sensitivity towards cytotoxic action of activated lymphocytes.


Hyperthermia Anticancer drugs Cytotoxicity Tumor cells Effectors of antitumor immunity 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Natalia Yu. Anisimova
    • 1
  • Irina Zh. Zhubina
    • 1
  • Fedor V. Donenko
    • 1
  • Julia I. Dolzhikova
    • 1
  • Antonina V. Kshnaykina
    • 1
  • Mikhail V. Kiselevskiy
    • 1
  1. 1.Laboratory of Cell ImmunityN.N. Blokhin National Medical Research CenterMoscowRussia

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