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Pathology of Selected Primary and Metastatic Tumors of Peritoneum

  • Kozlov A. Nikolay
Chapter

Abstract

Tumor pathology of the peritoneum is a vast field of activity for a practicing surgical pathologist. The variety of neoplastic lesions of the serous lining of the abdominal cavity is one of the most extensive in the diagnostic pathology. The tasks that the clinician poses for pathologist include not only verifying the pathological diagnosis of the tumor, but also determining the grade of malignancy, organ of origin, distinguishing of malignant and reactive processes. Successful solution of these tasks by a pathologist is a corner-stone of patient management, effectiveness of therapy, and finally, the survival of the patient. This chapter covers a number of rare pathological processes of the peritoneum, which sometimes can create significant diagnostic difficulties for pathologists.

Keywords

Malignant mesothelioma Pseudomyxoma peritonei Mesothelial lesions Peritoneal carcinomatosis Prognosis 

References

  1. 1.
    Husain AN, Colby T, Ordonez N, Krausz T, Attanoos R, Beasley MB et al (2013) Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the IMIG. Arch Pathol Lab Med 137(5):647–667CrossRefGoogle Scholar
  2. 2.
    Husain AN, Colby TV, Ordonez NG, Allen TC, Attanoos RL et al (2018) Guidelines for pathologic diagnosis of malignant mesothelioma 2017 update of the consensus statement from the IMIG. Arch Pathol Lab Med 142(1):89–108CrossRefGoogle Scholar
  3. 3.
    Alvorado-Cabrero I (2009) Pathology of the fallopian tube and broad ligament. In: Nucci MR, Oliva E (eds) Gynecologic pathology. Elsevier, Edinburgh/Churchill, pp 346–348Google Scholar
  4. 4.
    Daya D, Cheung ANY et al (2014) Mesothelial tumors. In: Kurman RJ, Carcangiu ML, Herrington S (eds) WHO classification of tumors of female reproductive organs. IARC, Lyon, pp 90–91Google Scholar
  5. 5.
    Levy AD, Arnaiz J, Shaw JC, Sobin LH (2008) From the archives of the AFIP: primary peritoneal tumors: imaging features with pathologic correlation. Radiographics 28(2):583–607CrossRefGoogle Scholar
  6. 6.
    Colgan TJ, Chang MC (2011) Fallopian tube and peritoneum. In: Soslow RA, Tornos C (eds) Diagnostic pathology of ovarian tumors. Springer, New York, pp 267–275CrossRefGoogle Scholar
  7. 7.
    Mok SC, Schorge JO, Weich WR et al (2003) Peritoneal tumors. In: Tavassoli FA, Devilee P (eds) WHO classification of tumors. Pathology & genetics of tumors of breast and female genital organs. IARC Press, Lyon, рp 197–202Google Scholar
  8. 8.
    Baker PM, Clement PB, Young RH (2005) Malignant peritoneal mesothelioma in women: a study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis. Am J Clin Pathol 123(5):724–737CrossRefGoogle Scholar
  9. 9.
    Henderson DW, Reid G, Kao SC, van Zandwijk N, Klebe S (2013) Challenges and controversies in the diagnosis of malignant mesothelioma: part 2. Malignant mesothelioma subtypes, pleural synovial sarcoma, molecular and prognostic aspects of mesothelioma, BAP1, aquaporin-1 and microRNA. J Clin Pathol 66(10):854–861CrossRefGoogle Scholar
  10. 10.
    Henderson DW, Reid G, Kao SC, van Zandwijk N, Klebe S (2013) Challenges and controversies in the diagnosis of mesothelioma: part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers. J Clin Pathol 66(10):847–853CrossRefGoogle Scholar
  11. 11.
    Travis WD, Brambilla E, Burke AP, Mrx A, Nicholson AG (2014) WHO classification of tumors of the kung, pleura, thymus and heart. IARC, LyonGoogle Scholar
  12. 12.
    Ordonez NG (2012) Deciduoid mesothelioma: report of 21 cases with review of the literature. Mod Pathol 25(11):1481–1495CrossRefGoogle Scholar
  13. 13.
    Ordonez NG (2012) Pleomorphic mesothelioma: report of 10 cases. Mod Pathol 25(7):1011–1022CrossRefGoogle Scholar
  14. 14.
    Klebe S, Brownlee NA, Mahar A, Burchette JL, Sporn TA, Vollmer RT, Roggli VL (2010) Sarcomatoid mesothelioma: a clinical-pathologic correlation of 326 cases. Mod Pathol 23(3):470–479CrossRefGoogle Scholar
  15. 15.
    Dabbs DJ (2010) Diagnostic immunohistochemistry: theranostic and genomic applications. Saunders, PhiladelphiaGoogle Scholar
  16. 16.
    Soomro IN, Oliveira R, Ronan J, Chaudry ZR, Johnson J (2005) Expression of mesothelial markers in malignant mesotheliomas: an immunohistochemical evaluation of 173 cases. J Pak Med Assoc 55(5):205–209PubMedGoogle Scholar
  17. 17.
    Suster S, Moran CA (2006) Applications and limitations of immunohistochemistry in the diagnosis of malignant mesothelioma. Adv Anat Pathol 13(6):316–329CrossRefGoogle Scholar
  18. 18.
    Attanoos RL, Dojcinov SD, Webb R, Gibbs AR (2000) Anti-mesothelial markers in sarcomatoid mesothelioma and other spindle cell neoplasms. Histopathology 37(3):224–231CrossRefGoogle Scholar
  19. 19.
    Lucas DR, Pass HI, Madan SK, Adsay NV, Wali A, Tabaczka P, Lonardo F (2003) Sarcomatoid mesothelioma and its histological mimics: a comparative immunohistochemical study. Histopathology 42(3):270–279CrossRefGoogle Scholar
  20. 20.
    Tandon RT, Jimenez-Cortez Y, Taub R, Borczuk AC (2018) Immunohistochemistry in peritoneal mesothelioma: a single-center experience of 244 cases. Arch Pathol Lab Med 142(2):236–242CrossRefGoogle Scholar
  21. 21.
    Ordonez NG (2013) Application of immunohistochemistry in the diagnosis of epithelioid mesothelioma: review and update. Hum Pathol 44:1–19CrossRefGoogle Scholar
  22. 22.
    Mangano WE, Cagle PT, Churg A, Vollmer RT, Roggli VL (1998) The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining. Am J Clin Pathol 110(2):191–199CrossRefGoogle Scholar
  23. 23.
    Fletcher CDM, Bridge JA, Lee JC (2013) Extrapleural solitary fibrous tumor. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F (eds) WHO classification of tumors of soft tissue and bone. Lyon, IARC Press, pp 80–83Google Scholar
  24. 24.
    Weiss SW, Goldblum JR (2008) Enzinger and Weiss’s soft tissue tumors, 5th edn. Mosby Elsevier, PhiladelphiaGoogle Scholar
  25. 25.
    Bahrami A, Luan DT, Jae YR (2008) Undifferentiated tumor: true identity by immunohistochemistry. Arch Pathol Lab Med 132:326–348PubMedGoogle Scholar
  26. 26.
    Clement PB, Young RH (2010) The peritoneum. In: Mills SE (ed) Sternberg’s diagnostic surgical pathology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pр 2393–2412Google Scholar
  27. 27.
    Carr NJ, Emory TS, Sobin LH (2003) Epithelial neoplasms of the appendix. In: Odze RD, Goldblum RG (eds) Surgical pathology of the GI tract, liver, biliary tract and pancreas. IARC Press, Lyon, pр 645–647Google Scholar
  28. 28.
    Carr NJ, Sobin LH (2010) Adenocarcinoma of the appendix. In: Bosman FT, Carneiro F, Hruban RH et al (eds) WHO classification of tumors of the digestive system. IARC, Lyon, pр 122–124Google Scholar
  29. 29.
    Yemelyanova A, Seidman JD (2011) Metastatic tumors. In: Soslow RA, Tornos C (eds) Diagnostic pathology of ovarian tumors. Springer, New York, pp 140–143Google Scholar
  30. 30.
    Vang R, Ronnett BM (2009) Metastatic and miscellaneous tumors of the ovary. In: Nucci MR, Oliva E (eds) Gynecologic pathology. Elsevier, Philadelphia, pp 539–564CrossRefGoogle Scholar
  31. 31.
    Terada T (2013) An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: expression of EMA, CEA, CA19–9, CDX-2, p53, Ki-67 antigen, TTF-1 and p63 in normal mucosa and in 42 cases. Int J Clin Exp Pathol 6(4):630–638PubMedPubMedCentralGoogle Scholar
  32. 32.
    Terada T (2013) An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: cytokeratin profile in 42 cases. Int J Clin Exp Pathol 6(4):703–710PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Kozlov A. Nikolay
    • 1
  1. 1.Department of PathologyN.N. Blokhin National Medical Research CenterMoscowRussia

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