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Rare Spinal Cord Tumors

  • Nir Shimony
  • Brooks Osburn
  • Sara Hartnett
  • Mari Groves
  • George I. JalloEmail author
Chapter

Abstract

Historically, spinal cord tumors represent approximately 15% of all primary central nervous system (CNS) tumors, whereas the newest classification of these intramedullary spinal cord tumors (IMSCTs) encompasses only 2–4% of all CNS tumors. The more prevalent intramedullary lesions include astrocytoma and ependymoma, which are thoroughly described elsewhere in this book. Astrocytoma followed by ependymoma are the most common IMSCTs found in children, while in adults ependymomas are more frequent. The less common IMSCTs are hemangioblastoma and spinal cord metastases, which are much more common in the adult population. Exceedingly rare lesions, such as lymphoma, primitive neuroectodermal tumor (PNET), lipoma, and neuroenteric cysts, paraganglioma, ganglioneuroma, and oligodendroglioma—among others—have been documented in both the adult and pediatric literature and will be elaborated on in this chapter. Spinal cord hemangioblastoma, spinal cord metastases, and spinal cord cavernous angioma are thoroughly described elsewhere in this book.

Keywords

Intramedullary Spinal Cord Tumors Astrocytoma Ependymoma Hemangioblastoma Spinal Cord Metastases Lymphoma Primitive Neuroectodermal Tumor Lipoma Neuroenteric Cysts Paraganglioma Ganglioneuroma Oligodendroglioma 

References

  1. 1.
    Kopelson G, Linggood RM, Kleinman GM, Doucette J, Wang CC. Management of intramedullary spinal cord tumors. Radiology. 1980;135(2):473–9.  https://doi.org/10.1148/radiology.135.2.7367644.PubMedCrossRefGoogle Scholar
  2. 2.
    Abul-Kasim K, Thurnher MM, McKeever P, Sundgren PC. Intradural spinal tumors: current classification and MRI features. Neuroradiology. 2008;50(4):301–14.  https://doi.org/10.1007/s00234-007-0345-7.PubMedCrossRefGoogle Scholar
  3. 3.
    Jallo GI, Freed D, Epstein F. Intramedullary spinal cord tumors in children. Childs Nerv Syst. 2003;19(9):641–9.  https://doi.org/10.1007/s00381-003-0820-3.CrossRefGoogle Scholar
  4. 4.
    Mirone G, Cinalli G, Spennato P, Ruggiero C, Aliberti F. Hydrocephalus and spinal cord tumors: a review. Childs Nerv Syst. 2011;27(10):1741–9.  https://doi.org/10.1007/s00381-011-1543-5.PubMedPubMedCentralCrossRefGoogle Scholar
  5. 5.
    Arima H, Hasegawa T, Togawa D, Yamato Y, Kobayashi S, Yasuda T, Matsuyama Y. Feasibility of a novel diagnostic chart of intramedullary spinal cord tumors in magnetic resonance imaging. Spinal Cord. 2014;52(10):769–73.  https://doi.org/10.1038/sc.2014.127.PubMedCrossRefGoogle Scholar
  6. 6.
    Nakamizo T, Inoue H, Udaka F, Oda M, Kawai M, Uemura K, Takahashi M, Nishinaka K, Sawada H, Kameyama M, Koyama T. Magnetic resonance imaging of primary spinal intramedullary lymphoma. J Neuroimaging. 2002;12(2):183–6.PubMedCrossRefGoogle Scholar
  7. 7.
    Flanagan EP, O'Neill BP, Porter AB, Lanzino G, Haberman TM, Keegan BM. Primary intramedullary spinal cord lymphoma. Neurology. 2011;77(8):784–91.  https://doi.org/10.1212/WNL.0b013e31822b00b9.PubMedCrossRefGoogle Scholar
  8. 8.
    Duan XH, Ban XH, Liu B, Zhong XM, Guo RM, Zhang F, Liang BL, Shen J. Intraspinal primitive neuroectodermal tumor: imaging findings in six cases. Eur J Radiol. 2011;80(2):426–31.  https://doi.org/10.1016/j.ejrad.2010.06.005.PubMedCrossRefGoogle Scholar
  9. 9.
    Shen SH, Lirng JF, Chang FC, Lee JY, Luo CB, Chen SS, Teng MM, Chang CY. Magnetic resonance imaging appearance of intradural spinal lipoma. Zhonghua Yi Xue Za Zhi (Taipei). 2001;64(6):364–8.Google Scholar
  10. 10.
    Patwardhan V, Patanakar T, Patkar D, Armao D, Mukherji SK. MR imaging findings of intramedullary lipomas. AJR Am J Roentgenol. 2000;174(6):1792–3.  https://doi.org/10.2214/ajr.174.6.1741792.PubMedCrossRefGoogle Scholar
  11. 11.
    Kimura H, Nagatomi A, Ochi M, Kurisu K. Intracranial neurenteric cyst with recurrence and extensive craniospinal dissemination. Acta Neurochir (Wien). 2006;148(3):347–52.; discussion 352.  https://doi.org/10.1007/s00701-005-0714-0.CrossRefGoogle Scholar
  12. 12.
    Muzumdar D, Bhatt Y, Sheth J. Intramedullary cervical neurenteric cyst mimicking an abscess. Pediatr Neurosurg. 2008;44(1):55–61.  https://doi.org/10.1159/000110664.PubMedCrossRefGoogle Scholar
  13. 13.
    Menezes AH, Traynelis VC. Spinal neurenteric cysts in the magnetic resonance imaging era. Neurosurgery. 2006;58(1):97–105. discussion 197-105PubMedCrossRefGoogle Scholar
  14. 14.
    Hoeffel C, Boukobza M, Polivka M, Lot G, Guichard JP, Lafitte F, Reizine D, Merland JJ. MR manifestations of subependymomas. AJNR Am J Neuroradiol. 1995;16(10):2121–9.PubMedGoogle Scholar
  15. 15.
    Patel U, Pinto RS, Miller DC, Handler MS, Rorke LB, Epstein FJ, Kricheff II. MR of spinal cord ganglioglioma. AJNR Am J Neuroradiol. 1998;19(5):879–87.Google Scholar
  16. 16.
    Epstein FJ, Farmer JP, Freed D. Adult intramedullary spinal cord ependymomas: the result of surgery in 38 patients. J Neurosurg. 1993;79(2):204–9.  https://doi.org/10.3171/jns.1993.79.2.0204.PubMedPubMedCentralCrossRefGoogle Scholar
  17. 17.
    Morota N, Deletis V, Constantini S, Kofler M, Cohen H, Epstein FJ. The role of motor evoked potentials during surgery for intramedullary spinal cord tumors. Neurosurgery. 1997;41(6):1327–36.PubMedPubMedCentralCrossRefGoogle Scholar
  18. 18.
    Tobin MK, Geraghty JR, Engelhard HH, Linninger AA, Mehta AI. Intramedullary spinal cord tumors: a review of current and future treatment strategies. Neurosurg Focus. 2015;39(2):E14.  https://doi.org/10.3171/2015.5.FOCUS15158.CrossRefGoogle Scholar
  19. 19.
    Hirose T, Scheithauer BW, Lopes MB, Gerber HA, Altermatt HJ, VandenBerg SR. Ganglioglioma: an ultrastructural and immunohistochemical study. Cancer. 1997;79(5):989–1003.PubMedCrossRefGoogle Scholar
  20. 20.
    Khajavi K, Comair YG, Prayson RA, Wyllie E, Palmer J, Estes ML, Hahn JF. Childhood ganglioglioma and medically intractable epilepsy. A clinicopathological study of 15 patients and a review of the literature. Pediatr Neurosurg. 1995;22(4):181–8.  https://doi.org/10.1159/000120899.PubMedCrossRefGoogle Scholar
  21. 21.
    Hamburger C, Büttner A, Weis S. Ganglioglioma of the spinal cord: report of two rare cases and review of the literature. Neurosurgery. 1997;41(6):1410–5. discussion 1415-1416PubMedCrossRefGoogle Scholar
  22. 22.
    Park CK, Chung CK, Choe GY, Wang KC, Cho BK, Kim HJ. Intramedullary spinal cord ganglioglioma: a report of five cases. Acta Neurochir (Wien). 2000;142(5):547–52.CrossRefGoogle Scholar
  23. 23.
    Hall WA, Yunis EJ, Albright AL. Anaplastic ganglioglioma in an infant: case report and review of the literature. Neurosurgery. 1986;19(6):1016–20.PubMedCrossRefGoogle Scholar
  24. 24.
    Wolf HK, Müller MB, Spänle M, Zentner J, Schramm J, Wiestler OD. Ganglioglioma: a detailed histopathological and immunohistochemical analysis of 61 cases. Acta Neuropathol. 1994;88(2):166–73.PubMedCrossRefGoogle Scholar
  25. 25.
    Blümcke I, Wiestler OD. Gangliogliomas: an intriguing tumor entity associated with focal epilepsies. J Neuropathol Exp Neurol. 2002;61(7):575–84.PubMedCrossRefGoogle Scholar
  26. 26.
    Kuten J, Kaidar-Person O, Vlodavsky E, Postovsky S, Billan S, Kuten A, Bortnyak-Abdah R. Anaplastic ganglioglioma in the spinal cord: case report and literature review. Pediatr Neurosurg. 2012;48(4):245–8.  https://doi.org/10.1159/000348556.PubMedCrossRefGoogle Scholar
  27. 27.
    Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, Miller DC. Central nervous system gangliogliomas. Part 2: Clinical outcome. J Neurosurg. 1993;79(6):867–73.  https://doi.org/10.3171/jns.1993.79.6.0867.PubMedCrossRefGoogle Scholar
  28. 28.
    Satyarthee GD, Mehta VS, Vaishya S. Ganglioglioma of the spinal cord: report of two cases and review of literature. J Clin Neurosci. 2004;11(2):199–203.PubMedCrossRefGoogle Scholar
  29. 29.
    Oppenheimer DC, Johnson MD, Judkins AR. Ganglioglioma of the Spinal Cord. J Clin Imaging Sci. 2015;5:53.  https://doi.org/10.4103/2156-7514.166355.PubMedPubMedCentralCrossRefGoogle Scholar
  30. 30.
    Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131(6):803–20.  https://doi.org/10.1007/s00401-016-1545-1.CrossRefGoogle Scholar
  31. 31.
    Horbinski C. To BRAF or not to BRAF: is that even a question anymore? J Neuropathol Exp Neurol. 2013;72(1):2–7.  https://doi.org/10.1097/NEN.0b013e318279f3db.PubMedPubMedCentralCrossRefGoogle Scholar
  32. 32.
    Wang JL, Hong CS, Otero J, Puduvalli VK, Elder JB. Genetic Characterization of a Multifocal Ganglioglioma Originating Within the Spinal Cord. World Neurosurg 96:608.e601-608.e604. 2016;  https://doi.org/10.1016/j.wneu.2016.09.063.PubMedPubMedCentralCrossRefGoogle Scholar
  33. 33.
    Dougherty MJ, Santi M, Brose MS, Ma C, Resnick AC, Sievert AJ, Storm PB, Biegel JA. Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro Oncol. 2010;12(7):621–30.  https://doi.org/10.1093/neuonc/noq007.PubMedPubMedCentralCrossRefGoogle Scholar
  34. 34.
    Schindler G, Capper D, Meyer J, Janzarik W, Omran H, Herold-Mende C, Schmieder K, Wesseling P, Mawrin C, Hasselblatt M, Louis DN, Korshunov A, Pfister S, Hartmann C, Paulus W, Reifenberger G, von Deimling A. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma. Acta Neuropathol. 2011;121(3):397–405.  https://doi.org/10.1007/s00401-011-0802-6.CrossRefGoogle Scholar
  35. 35.
    Johnson JH, Hariharan S, Berman J, Sutton LN, Rorke LB, Molloy P, Phillips PC. Clinical outcome of pediatric gangliogliomas: ninety-nine cases over 20 years. Pediatr Neurosurg. 1997;27(4):203–7.  https://doi.org/10.1159/000121252.PubMedCrossRefGoogle Scholar
  36. 36.
    Otsubo H, Hoffman HJ, Humphreys RP, Hendrick EB, Drake JM, Hwang PA, Becker LE, Chuang SH. Detection and management of gangliogliomas in children. Surg Neurol. 1992;38(5):371–8.PubMedCrossRefGoogle Scholar
  37. 37.
    Haddad SF, Moore SA, Menezes AH, VanGilder JC. Ganglioglioma: 13 years of experience. Neurosurgery. 1992;31(2):171–8.PubMedCrossRefGoogle Scholar
  38. 38.
    Kalyan-Raman UP, Olivero WC. Ganglioglioma: a correlative clinicopathological and radiological study of ten surgically treated cases with follow-up. Neurosurgery. 1987;20(3):428–33.PubMedCrossRefGoogle Scholar
  39. 39.
    Johannsson JH, Rekate HL, Roessmann U. Gangliogliomas: pathological and clinical correlation. J Neurosurg. 1981;54(1):58–63.  https://doi.org/10.3171/jns.1981.54.1.0058.PubMedCrossRefGoogle Scholar
  40. 40.
    Lv G, Lu L, Dai Z. Paragangliomas of the Spine. Turk Neurosurg. 2017;27(3):401–7.  https://doi.org/10.5137/1019-5149.JTN.16276-15.1.PubMedCrossRefGoogle Scholar
  41. 41.
    Sundgren P, Annertz M, Englund E, Strömblad LG, Holtås S. Paragangliomas of the spinal canal. Neuroradiology. 1999;41(10):788–94.PubMedCrossRefGoogle Scholar
  42. 42.
    Mishra T, Goel NA, Goel AH. Primary paraganglioma of the spine: A clinicopathological study of eight cases. J Craniovertebr Junction Spine. 2014;5(1):20–4.  https://doi.org/10.4103/0974-8237.135211.PubMedPubMedCentralCrossRefGoogle Scholar
  43. 43.
    Böker DK, Wassmann H, Solymosi L. Paragangliomas of the spinal canal. Surg Neurol. 1983;19(5):461–8.PubMedCrossRefGoogle Scholar
  44. 44.
    Toyota B, Barr HW, Ramsay D. Hemodynamic activity associated with a paraganglioma of the cauda equina. Case report. J Neurosurg. 1993;79(3):451–5.  https://doi.org/10.3171/jns.1993.79.3.0451.PubMedCrossRefGoogle Scholar
  45. 45.
    Kwan RB, Erasmus AM, Hunn AW, Dubey A, Waites P, Jessup PJ, Burgess JR, Beasley A. Pre-operative embolisation of metastatic paraganglioma of the thoracic spine. J Clin Neurosci. 2010;17(3):394–6.  https://doi.org/10.1016/j.jocn.2009.05.030.PubMedCrossRefGoogle Scholar
  46. 46.
    Kalani MA, Chang SD, Vu B. Paraganglioma of the Filum Terminale: Case Report, Pathology and Review of the Literature. Cureus. 2015;7(10):e354.  https://doi.org/10.7759/cureus.354.PubMedPubMedCentralCrossRefGoogle Scholar
  47. 47.
    Choi DY, Lee HJ, Shin MH, Kim JT. Solitary cervical neurenteric cyst in an adolescent patient. J Korean Neurosurg Soc. 2015;57(2):135–9.  https://doi.org/10.3340/jkns.2015.57.2.135.PubMedPubMedCentralCrossRefGoogle Scholar
  48. 48.
    Yang T, Wu L, Fang J, Yang C, Deng X, Xu Y. Clinical presentation and surgical outcomes of intramedullary neurenteric cysts. J Neurosurg Spine. 2015;23(1):99–110.  https://doi.org/10.3171/2014.11.SPINE14352.PubMedCrossRefGoogle Scholar
  49. 49.
    Diaz-Aguilar D, Niu T, Terterov S, Scharnweber R, Tucker A, Woodard J, Brara H, Merna C, Shah H, Wang S, Rahman S. Neurenteric cyst of the conus medullaris. Surg Neurol Int. 2018;9:33.  https://doi.org/10.4103/sni.sni_315_17.PubMedPubMedCentralCrossRefGoogle Scholar
  50. 50.
    Takahashi S, Morikawa S, Saruhashi Y, Matsusue Y, Kawakami M. Percutaneous transthoracic fenestration of an intramedullary neurenteric cyst in the thoracic spine with intraoperative magnetic resonance image navigation and thoracoscopy. J Neurosurg Spine. 2008;9(5):488–92.  https://doi.org/10.3171/SPI.2008.9.11.488.PubMedCrossRefGoogle Scholar
  51. 51.
    Kwok DM, Jeffreys RV. Intramedullary enterogenous cyst of the spinal cord. Case report. J Neurosurg. 1982;56(2):270–4.  https://doi.org/10.3171/jns.1982.56.2.0270.PubMedCrossRefGoogle Scholar
  52. 52.
    Riviérez M, Buisson G, Kujas M, Ridarch A, Mignon E, Jouannelle A, René-Corail P. Intramedullary neurenteric cyst without any associated malformation. One case evaluated by RMI and electron microscopic study. Acta Neurochir (Wien). 1997;139(9):887–90.CrossRefGoogle Scholar
  53. 53.
    Silvernail WI, Brown RB. Intramedullary enterogenous cyst. Case report. J Neurosurg. 1972;36(2):235–8.  https://doi.org/10.3171/jns.1972.36.2.0235.PubMedCrossRefGoogle Scholar
  54. 54.
    Gomber S, Das DK, Rath B, Chadha V, Kapoor R, Saini L. Burkitt type lymphoma presenting as rapidly progressive proptosis. Indian Pediatr. 1989;26(3):296–300.PubMedGoogle Scholar
  55. 55.
    Hasturk AE, Gokce EC, Elbir C, Gel G, Canbay S. A very rare spinal cord tumor primary spinal oligodendroglioma: A review of sixty cases in the literature. J Craniovertebr Junction Spine. 2017;8(3):253–62.  https://doi.org/10.4103/jcvjs.JCVJS_1_17.PubMedPubMedCentralCrossRefGoogle Scholar
  56. 56.
    Fountas KN, Karampelas I, Nikolakakos LG, Troup EC, Robinson JS. Primary spinal cord oligodendroglioma: case report and review of the literature. Childs Nerv Syst. 2005;21(2):171–5.  https://doi.org/10.1007/s00381-004-0973-8.PubMedCrossRefGoogle Scholar
  57. 57.
    Tobias ME, McGirt MJ, Chaichana KL, Goldstein IM, Kothbauer KF, Epstein F, Jallo GI. Surgical management of long intramedullary spinal cord tumors. Childs Nerv Syst. 2008;24(2):219–23.  https://doi.org/10.1007/s00381-007-0405-7.PubMedCrossRefGoogle Scholar
  58. 58.
    Fortuna A, Celli P, Palma L. Oligodendrogliomas of the spinal cord. Acta Neurochir (Wien). 1980;52(3-4):305–29.CrossRefGoogle Scholar
  59. 59.
    Cruz REH, De Roxas RC, Sales-Callangan CCA, Jamora RDG. Holocord oligodendroglioma with intracranial extension in a young adult: a case report and review of literature. CNS oncology. 2018;7(1):1–5.  https://doi.org/10.2217/cns-2017-0012.PubMedPubMedCentralCrossRefGoogle Scholar
  60. 60.
    Ushida T, Sonobe H, Mizobuchi H, Toda M, Tani T, Yamamoto H. Oligodendroglioma of the "widespread" type in the spinal cord. Childs Nerv Syst. 1998;14(12):751–5.  https://doi.org/10.1007/s003810050310.PubMedCrossRefGoogle Scholar
  61. 61.
    Nam DH, Cho BK, Kim YM, Chi JG, Wang KC. Intramedullary anaplastic oligodendroglioma in a child. Childs Nerv Syst. 1998;14(3):127–30.  https://doi.org/10.1007/s003810050194.PubMedCrossRefGoogle Scholar
  62. 62.
    Bruzek AK, Zureick AH, McKeever PE, Garton HJL, Robertson PL, Mody R, Koschmann CJ. Molecular characterization reveals NF1 deletions and FGFR1-activating mutations in a pediatric spinal oligodendroglioma. Pediatric blood & cancer. 2017;64(6):e26346.  https://doi.org/10.1002/pbc.26346.CrossRefGoogle Scholar
  63. 63.
    Gilmer-Hill HS, Ellis WG, Imbesi SG, Boggan JE. Spinal oligodendroglioma with gliomatosis in a child. Case report. J Neurosurg. 2000;92(1 Suppl):109–13.PubMedGoogle Scholar
  64. 64.
    Wang KC, Chi JG, Cho BK. Oligodendroglioma in childhood. Journal of Korean medical science. 1993;8(2):110–6.  https://doi.org/10.3346/jkms.1993.8.2.110.PubMedPubMedCentralCrossRefGoogle Scholar
  65. 65.
    Sharma S, Sarkar C, Gaikwad S, Suri A, Sharma MC. Primary neurocytoma of the spinal cord: a case report and review of literature. Journal of neuro-oncology. 2005;74(1):47–52.  https://doi.org/10.1007/s11060-004-3348-9.PubMedCrossRefGoogle Scholar
  66. 66.
    Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114(2):97–109.  https://doi.org/10.1007/s00401-007-0243-4.PubMedPubMedCentralCrossRefGoogle Scholar
  67. 67.
    Li Z, Gao J, Wang T, Kong X, Guan J, Li Y. Intramedullary central neurocytoma of the thoracic spinal cord: A case report and literature review. Molecular and clinical oncology. 2018;8(4):544–8.  https://doi.org/10.3892/mco.2018.1570.PubMedPubMedCentralCrossRefGoogle Scholar
  68. 68.
    Tatter SB, Borges LF, Louis DN. Central neurocytomas of the cervical spinal cord. Report of two cases. J Neurosurg. 1994;81(2):288–93.  https://doi.org/10.3171/jns.1994.81.2.0288.PubMedCrossRefGoogle Scholar
  69. 69.
    Ahmad Z, Din NU, Memon A, Tariq MU, Idrees R, Hasan S. Central, Extraventricular and Atypical Neurocytomas: a Clinicopathologic Study of 35 Cases from Pakistan Plus a Detailed Review of the Published Literature. Asian Pacific journal of cancer prevention : APJCP. 2016;17(3):1565–70.PubMedCrossRefGoogle Scholar
  70. 70.
    Dodds D, Nonis J, Mehta M, Rampling R. Central neurocytoma: a clinical study of response to chemotherapy. Journal of neuro-oncology. 1997;34(3):279–83.PubMedCrossRefGoogle Scholar
  71. 71.
    Xu L, Ouyang Z, Wang J, Liu Z, Fang J, Du J, He Y, Li G. A clinicopathologic study of extraventricular neurocytoma. Journal of neuro-oncology. 2017;132(1):75–82.  https://doi.org/10.1007/s11060-016-2336-1.PubMedCrossRefGoogle Scholar
  72. 72.
    Gultekin SH, Dalmau J, Graus Y, Posner JB, Rosenblum MK. Anti-Hu immunolabeling as an index of neuronal differentiation in human brain tumors: a study of 112 central neuroepithelial neoplasms. Am J Surg Pathol. 1998;22(2):195–200.PubMedCrossRefGoogle Scholar
  73. 73.
    Soylemezoglu F, Onder S, Tezel GG, Berker M. Neuronal nuclear antigen (NeuN): a new tool in the diagnosis of central neurocytoma. Pathol Res Pract. 2003;199(7):463–8.  https://doi.org/10.1078/0344-0338-00446.PubMedCrossRefGoogle Scholar
  74. 74.
    Sweiss FB, Lee M, Sherman JH. Extraventricular neurocytomas. Neurosurg Clin N Am. 2015;26(1):99–104.  https://doi.org/10.1016/j.nec.2014.09.004.PubMedCrossRefGoogle Scholar
  75. 75.
    Brandes AA, Amista P, Gardiman M, Volpin L, Danieli D, Guglielmi B, Carollo C, Pinna G, Turazzi S, Monfardini S. Chemotherapy in patients with recurrent and progressive central neurocytoma. Cancer. 2000;88(1):169–74.PubMedCrossRefGoogle Scholar
  76. 76.
    Martin AJ, Sharr MM, Teddy PJ, Gardner BP, Robinson SF. Neurocytoma of the thoracic spinal cord. Acta Neurochir (Wien). 2002;144(8):823–8.  https://doi.org/10.1007/s00701-002-0980-z.CrossRefGoogle Scholar
  77. 77.
    Stapleton SR, David KM, Harkness WF, Harding BN (1997) Central neurocytoma of the cervical spinal cord. Journal of neurology, neurosurgery, and psychiatry 63 (1):119CrossRefGoogle Scholar
  78. 78.
    Iwasaki M, Hida K, Aoyama T, Houkin K. Thoracolumbar intramedullary subependymoma with multiple cystic formation: a case report and review. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 22 Suppl 3:S317-320. 2013;  https://doi.org/10.1007/s00586-012-2357-1.PubMedCentralCrossRefGoogle Scholar
  79. 79.
    Yuh WT, Chung CK, Park SH, Kim KJ, Lee SH, Kim KT. Spinal Cord Subependymoma Surgery : A Multi-Institutional Experience. J Korean Neurosurg Soc. 2018;61(2):233–42.  https://doi.org/10.3340/jkns.2017.0405.001.PubMedPubMedCentralCrossRefGoogle Scholar
  80. 80.
    Rushing EJ, Cooper PB, Quezado M, Begnami M, Crespo A, Smirniotopoulos JG, Ecklund J, Olsen C, Santi M. Subependymoma revisited: clinicopathological evaluation of 83 cases. Journal of neuro-oncology. 2007;85(3):297–305.  https://doi.org/10.1007/s11060-007-9411-6.PubMedCrossRefGoogle Scholar
  81. 81.
    Bi Z, Ren X, Zhang J, Jia W. Clinical, radiological, and pathological features in 43 cases of intracranial subependymoma. J Neurosurg. 2015;122(1):49–60.  https://doi.org/10.3171/2014.9.jns14155.PubMedCrossRefGoogle Scholar
  82. 82.
    Krishnan SS, Panigrahi M, Pendyala S, Rao SI, Varma DR. Cervical Subependymoma: A rare case report with possible histogenesis. Journal of neurosciences in rural practice. 2012;3(3):366–9.  https://doi.org/10.4103/0976-3147.102630.PubMedPubMedCentralCrossRefGoogle Scholar
  83. 83.
    Matsumoto K, Nakagaki H. Intramedullary subependymoma occupying the right half of the thoracic spinal cord--case report. Neurologia medico-chirurgica. 2002;42(8):349–53.PubMedCrossRefGoogle Scholar
  84. 84.
    Orakcioglu B, Schramm P, Kohlhof P, Aschoff A, Unterberg A, Halatsch ME. Characteristics of thoracolumbar intramedullary subependymomas. J Neurosurg Spine. 2009;10(1):54–9.  https://doi.org/10.3171/2008.10.spi08311.PubMedCrossRefGoogle Scholar
  85. 85.
    Kremer P, Zoubaa S, Schramm P. Intramedullary subependymoma of the lower spinal cord. British journal of neurosurgery. 2004;18(5):548–51.PubMedCrossRefGoogle Scholar
  86. 86.
    Jallo GI, Zagzag D, Epstein F. Intramedullary subependymoma of the spinal cord. Neurosurgery. 1996;38(2):251–7.PubMedCrossRefGoogle Scholar
  87. 87.
    Wu L, Yang T, Deng X, Yang C, Zhao L, Fang J, Wang G, Yang J, Xu Y. Surgical outcomes in spinal cord subependymomas: an institutional experience. Journal of neuro-oncology. 2014;116(1):99–106.  https://doi.org/10.1007/s11060-013-1256-6.PubMedCrossRefGoogle Scholar
  88. 88.
    Jang WY, Lee JK, Lee JH, Kim JH, Kim SH, Lee KH, Lee MC. Intramedullary subependymoma of the thoracic spinal cord. J Clin Neurosci. 2009;16(6):851–3.  https://doi.org/10.1016/j.jocn.2008.09.008.PubMedCrossRefGoogle Scholar
  89. 89.
    Borg M. Germ cell tumours of the central nervous system in children-controversies in radiotherapy. Med Pediatr Oncol. 2003;40(6):367–74.  https://doi.org/10.1002/mpo.10285.PubMedCrossRefGoogle Scholar
  90. 90.
    Hanakita S, Takenobu A, Kambe A, Watanabe T, Shin M, Teraoka A. Intramedullary recurrence of germinoma in the spinal cord 15 years after complete remission of a pineal lesion. J Neurosurg Spine. 2012;16(5):513–5.  https://doi.org/10.3171/2012.2.spine11499.PubMedCrossRefGoogle Scholar
  91. 91.
    Ogawa K, Yoshii Y, Shikama N, Nakamura K, Uno T, Onishi H, Itami J, Shioyama Y, Iraha S, Hyodo A, Toita T, Kakinohana Y, Tamaki W, Ito H, Murayama S. Spinal recurrence from intracranial germinoma: risk factors and treatment outcome for spinal recurrence. Int J Radiat Oncol Biol Phys. 2008;72(5):1347–54.  https://doi.org/10.1016/j.ijrobp.2008.03.055.PubMedCrossRefGoogle Scholar
  92. 92.
    Loya JJ, Jung H, Temmins C, Cho N, Singh H. Primary spinal germ cell tumors: a case analysis and review of treatment paradigms. Case reports in medicine. 2013;2013:798358–6.  https://doi.org/10.1155/2013/798358.PubMedPubMedCentralCrossRefGoogle Scholar
  93. 93.
    Nikitovic M, Grujicic D, Skender Gazibara M, Stanic D, Bokun J, Saric M. Intramedullary Spinal Cord Germinoma: A Case Report and Review of Literature. World Neurosurg. 2016;95:392–8.  https://doi.org/10.1016/j.wneu.2016.08.039.PubMedCrossRefGoogle Scholar
  94. 94.
    Lu NH, Chen CY, Chou JM, Kuo TH, Yeh CH. MR imaging of primary spinal germinoma: a case report and review of the literature. J Neuroimaging. 2009;19(1):92–6.  https://doi.org/10.1111/j.1552-6569.2007.00214.x.PubMedCrossRefGoogle Scholar
  95. 95.
    Chute DJ, Burton EC, Klement IA, Frazee JG, Vinters HV. Primary intramedullary spinal cord germinoma: case report. Journal of neuro-oncology. 2003;63(1):69–73.PubMedCrossRefGoogle Scholar
  96. 96.
    Matsuyama Y, Nagasaka T, Mimatsu K, Inoue K, Mii K, Iwata H. Intramedullary spinal cord germinoma. Spine. 1995;20(21):2338–40.PubMedCrossRefGoogle Scholar
  97. 97.
    Watanabe A, Horikoshi T, Naganuma H, Satoh E, Nukui H. Intramedullary spinal cord germinoma expresses the protooncogene c-kit. Acta Neurochir (Wien). 2005;147(3):303–8.; discussion 308.  https://doi.org/10.1007/s00701-004-0450-x.CrossRefGoogle Scholar
  98. 98.
    Hanafusa K, Shibuya H, Abe M, Yamaura K, Suzuki S. Intramedullary spinal cord germinoma. Case report and review of the literature. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 1993;159(2):203–4.  https://doi.org/10.1055/s-2008-1032749.PubMedCrossRefGoogle Scholar
  99. 99.
    Wu L, Yang T, Deng X, Yang C, Fang J, Xu Y. Treatment strategies and long-term outcomes for primary intramedullary spinal germinomas: an institutional experience. Journal of neuro-oncology. 2015;121(3):541–8.  https://doi.org/10.1007/s11060-014-1662-4.PubMedCrossRefGoogle Scholar
  100. 100.
    Yamagata T, Takami T, Tsuyuguchi N, Goto T, Wakasa K, Ohata K. Primary intramedullary spinal cord germinoma: diagnostic challenge and treatment strategy. Neurologia medico-chirurgica. 2009;49(3):128–33.PubMedCrossRefGoogle Scholar
  101. 101.
    Sawamura Y, Kato T, Ikeda J, Murata J, Tada M, Shirato H. Teratomas of the central nervous system: treatment considerations based on 34 cases. J Neurosurg. 1998;89(5):728–37.  https://doi.org/10.3171/jns.1998.89.5.0728.PubMedCrossRefGoogle Scholar
  102. 102.
    Liu Z, Lv X, Wang W, An J, Duan F, Feng X, Chen X, Ouyang B, Li S, Singh S, Qiu S. Imaging characteristics of primary intracranial teratoma. Acta radiologica (Stockholm, Sweden : 1987). 2014;55(7):874–81.  https://doi.org/10.1177/0284185113507824.CrossRefGoogle Scholar
  103. 103.
    Turan N, Halani SH, Baum GR, Neill SG, Hadjipanayis CG. Adult Intramedullary Teratoma of the Spinal Cord: A Case Report and Review of Literature. World Neurosurg 87:661.e623-630. 2016;  https://doi.org/10.1016/j.wneu.2015.10.053.CrossRefGoogle Scholar
  104. 104.
    Arai Y, Takahashi M, Takeda K, Shitoto K. Adult-onset intradural spinal teratoma in the lumbar spine: A case report. Journal of orthopaedic surgery (Hong Kong). 2000;8(2):69–74.  https://doi.org/10.1177/230949900000800213.CrossRefGoogle Scholar
  105. 105.
    Jian W, Ying W, Chao Y. Intramedullary spinal teratoma of the conus medullaris: report of two cases. Acta Neurochir (Wien). 2010;152(3):553–4.  https://doi.org/10.1007/s00701-009-0466-3.CrossRefGoogle Scholar
  106. 106.
    Makary R, Wolfson D, Dasilva V, Mohammadi A, Shuja S. Intramedullary mature teratoma of the cervical spinal cord at C1-2 associated with occult spinal dysraphism in an adult. Case report and review of the literature. J Neurosurg Spine. 2007;6(6):579–84.  https://doi.org/10.3171/spi.2007.6.6.12.PubMedCrossRefGoogle Scholar
  107. 107.
    Moon HJ, Shin BK, Kim JH, Kwon TH, Chung HS, Park YK. Adult cervical intramedullary teratoma: first reported immature case. J Neurosurg Spine. 2010;13(2):283–7.  https://doi.org/10.3171/2010.3.spine09461.PubMedCrossRefGoogle Scholar
  108. 108.
    Monajati A, Spitzer RM, Wiley JL, Heggeness L. MR imaging of a spinal teratoma. Journal of computer assisted tomography. 1986;10(2):307–10.PubMedCrossRefGoogle Scholar
  109. 109.
    Allsopp G, Sgouros S, Barber P, Walsh AR. Spinal teratoma: is there a place for adjuvant treatment? Two cases and a review of the literature. British journal of neurosurgery. 2000;14(5):482–8.PubMedCrossRefGoogle Scholar
  110. 110.
    Nonomura Y, Miyamoto K, Wada E, Hosoe H, Nishimoto H, Ogura H, Shimizu K. Intramedullary teratoma of the spine: report of two adult cases. Spinal Cord. 2002;40(1):40–3.  https://doi.org/10.1038/sj.sc.3101247.PubMedCrossRefGoogle Scholar
  111. 111.
    Koen JL, McLendon RE, George TM. Intradural spinal teratoma: evidence for a dysembryogenic origin. Report of four cases. J Neurosurg. 1998;89(5):844–51.  https://doi.org/10.3171/jns.1998.89.5.0844.PubMedCrossRefGoogle Scholar
  112. 112.
    Park SC, Kim KJ, Wang KC, Choe G, Kim HJ. Spinal epidural teratoma: review of spinal teratoma with consideration on the pathogenesis: case report. Neurosurgery. 2010;67(6):E1818–25.  https://doi.org/10.1227/NEU.0b013e3181f846ca.PubMedCrossRefGoogle Scholar
  113. 113.
    Isik N, Balak N, Silav G, Elmaci I. Pediatric intramedullary teratomas. Neuropediatrics. 2008;39(4):196–9.  https://doi.org/10.1055/s-0028-1112116.PubMedCrossRefGoogle Scholar
  114. 114.
    Roux A, Mercier C, Larbrisseau A, Dube LJ, Dupuis C, Del Carpio R. Intramedullary epidermoid cysts of the spinal cord. Case report. J Neurosurg. 1992;76(3):528–33.  https://doi.org/10.3171/jns.1992.76.3.0528.PubMedCrossRefGoogle Scholar
  115. 115.
    Cataltepe O, Berker M, Akalan N. A giant intramedullary spinal epidermoid cyst of the cervicothoracic region. Pediatr Neurosurg. 2004;40(3):120–3.  https://doi.org/10.1159/000079853.PubMedCrossRefGoogle Scholar
  116. 116.
    Tekkok IH, Palaoglu S, Erbengi A, Onol B. Intramedullary epidermoid cyst of the cervical spinal cord associated with an extraspinal neuroenteric cyst: case report. Neurosurgery. 1992;31(1):121–5.PubMedCrossRefGoogle Scholar
  117. 117.
    Chandra PS, Manjari T, Devi BI, Chandramouli BA, Srikanth SG, Shankar SK. Intramedullary spinal epidermoid cyst. Neurology India. 2000;48(1):75–7.PubMedGoogle Scholar
  118. 118.
    Falavigna A, Righesso O, Teles AR. Concomitant dermoid cysts of conus medullaris and cauda equina. Arquivos de neuro-psiquiatria. 2009;67(2a):293–6.PubMedCrossRefGoogle Scholar
  119. 119.
    Vadivelu S, Desai SK, Illner A, Luerssen TG, Jea A. Infected lumbar dermoid cyst mimicking intramedullary spinal cord tumor: Observations and outcomes. Journal of pediatric neurosciences. 2014;9(1):21–6.  https://doi.org/10.4103/1817-1745.131475.PubMedPubMedCentralCrossRefGoogle Scholar
  120. 120.
    Guidetti B, Gagliardi FM. Epidermoid and dermoid cysts. Clinical evaluation and late surgical results. J Neurosurg. 1977;47(1):12–8.  https://doi.org/10.3171/jns.1977.47.1.0012.PubMedCrossRefGoogle Scholar
  121. 121.
    Girishan S, Rajshekhar V. Rapid-onset paraparesis and quadriparesis in patients with intramedullary spinal dermoid cysts: report of 10 cases. Journal of neurosurgery Pediatrics. 2016;17(1):86–93.  https://doi.org/10.3171/2015.5.peds1537.PubMedCrossRefGoogle Scholar
  122. 122.
    Chan CT, Gold WL. Intramedullary abscess of the spinal cord in the antibiotic era: clinical features, microbial etiologies, trends in pathogenesis, and outcomes. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 1998;27(3):619–26.CrossRefGoogle Scholar
  123. 123.
    Simon JK, Lazareff JA, Diament MJ, Kennedy WA. Intramedullary abscess of the spinal cord in children: a case report and review of the literature. The Pediatric infectious disease journal. 2003;22(2):186–92.  https://doi.org/10.1097/01.inf.0000048910.19136.49.PubMedCrossRefGoogle Scholar
  124. 124.
    Morandi X, Mercier P, Fournier HD, Brassier G. Dermal sinus and intramedullary spinal cord abscess. Report of two cases and review of the literature. Childs Nerv Syst. 1999;15(4):202–6. discussion 207-208PubMedCrossRefGoogle Scholar
  125. 125.
    Cha JG, Paik SH, Park JS, Park SJ, Kim DH, Lee HK. Ruptured spinal dermoid cyst with disseminated intracranial fat droplets. The British journal of radiology. 2006;79(938):167–9.  https://doi.org/10.1259/bjr/17232685.PubMedCrossRefGoogle Scholar
  126. 126.
    Tufan K, Cekinmez M, Sener L, Erdogan B. Infected lumbar dermoid cyst presenting with tetraparesis secondary to holocord central lesion. Journal of child neurology. 2008;23(8):934–7.  https://doi.org/10.1177/0883073808314961.PubMedCrossRefGoogle Scholar
  127. 127.
    Shah JR, Joshi V, Patkar D. Dorsal dermal sinus with intramedullary abscess formation. Australasian radiology. 2007;51(Suppl):B205–9.  https://doi.org/10.1111/j.1440-1673.2007.01836.x.PubMedCrossRefGoogle Scholar
  128. 128.
    Wilson PE, Oleszek JL, Clayton GH. Pediatric spinal cord tumors and masses. J Spinal Cord Med. 2007;30(Suppl 1):S15–20.PubMedPubMedCentralCrossRefGoogle Scholar
  129. 129.
    Patel MR, Tse V. Diagnosis and staging of brain tumors. Seminars in roentgenology. 2004;39(3):347–60.PubMedCrossRefGoogle Scholar
  130. 130.
    Suocheng G, Yazhou X. A review on five cases of intramedullary dermoid cyst. Childs Nerv Syst. 2014;30(4):659–64.  https://doi.org/10.1007/s00381-013-2281-7.PubMedCrossRefGoogle Scholar
  131. 131.
    Houx L, Brochard S, Peudenier S, Dam Hieu P, Remy-Neris O. Recovery after tetraplegia caused by dermal sinus infection: intramedullary abscess and tetraparesis. Pediatric neurology. 2011;44(3):229–32.  https://doi.org/10.1016/j.pediatrneurol.2010.10.017.PubMedCrossRefGoogle Scholar
  132. 132.
    Stevens WW, Schlesinger ED. Intramedullary epidermoid tumors of the thoracic spinal cord. Report of two cases. J Neurosurg. 1968;29(3):296–9.  https://doi.org/10.3171/jns.1968.29.3.0296.PubMedCrossRefGoogle Scholar
  133. 133.
    Zavanone M, Guerra P, Rampini PM, Crotti F, Vaccari U. A cervico-dorsal intramedullary epidermoid cyst. Case report and review of the literature. Journal of neurosurgical sciences. 1991;35(2):111–5.PubMedGoogle Scholar
  134. 134.
    Biliciler B, Vatansever M, Fuat Erten S, Sarac K, Colak A. A huge intramedullary epidermoid cyst: mimicking cauda equina ependymoma. Diagnostic failure of myelography and myelo-CT. Journal of neurosurgical sciences. 1996;40(2):149–52.PubMedGoogle Scholar
  135. 135.
    Martinez-Lage JF, Esteban JA, Poza M, Casas C. Congenital dermal sinus associated with an abscessed intramedullary epidermoid cyst in a child: case report and review of the literature. Childs Nerv Syst. 1995;11(5):301–5.PubMedCrossRefGoogle Scholar
  136. 136.
    Bristow RG, Laperriere NJ, Tator C, Milosevic M, Wong CS. Post-operative radiotherapy for recurrent dermoid cysts of the spine: a report of 3 cases. Journal of neuro-oncology. 1997;33(3):251–6.PubMedCrossRefGoogle Scholar
  137. 137.
    CARAM PC, CARTON CA, SCARCELLA G. Intradural lipomas of the spinal cord; with particular emphasis on the intramedullary lipomas. J Neurosurg. 1957;14(1):28–42.  https://doi.org/10.3171/jns.1957.14.1.0028.PubMedCrossRefGoogle Scholar
  138. 138.
    Pang D, Zovickian J, Wong ST, Hou YJ, Moes GS. Surgical treatment of complex spinal cord lipomas. Childs Nerv Syst. 2013;29(9):1485–513.  https://doi.org/10.1007/s00381-013-2187-4.PubMedPubMedCentralCrossRefGoogle Scholar
  139. 139.
    Meher SK, Tripathy LN, Jain H, Basu S. Nondysraphic cervicomedullary intramedullary lipoma. J Craniovertebr Junction Spine. 2017;8(3):271–4.  https://doi.org/10.4103/jcvjs.JCVJS_130_16.PubMedPubMedCentralCrossRefGoogle Scholar
  140. 140.
    Lee M, Rezai AR, Abbott R, Coelho DH, Epstein FJ. Intramedullary spinal cord lipomas. J Neurosurg. 1995;82(3):394–400.  https://doi.org/10.3171/jns.1995.82.3.0394.PubMedCrossRefGoogle Scholar
  141. 141.
    Bhatoe HS, Singh P, Chaturvedi A, Sahai K, Dutta V, Sahoo PK (2005) Nondysraphic intramedullary spinal cord lipomas: a review. Neurosurg Focus 18 (2):Ecp1Google Scholar
  142. 142.
    Ahmed O, Zhang S, Thakur JD, Nanda A. Nondysraphic Intramedullary Cervical Cord Lipoma with Exophytic Component: Case Report. Journal of neurological surgery reports. 2015;76(1):e87–90.  https://doi.org/10.1055/s-0035-1547367.PubMedPubMedCentralCrossRefGoogle Scholar
  143. 143.
    Grimm S, Chamberlain MC. Adult primary spinal cord tumors. Expert Rev Neurother. 2009;9(10):1487–95.  https://doi.org/10.1586/ern.09.101.CrossRefGoogle Scholar
  144. 144.
    Houten JK, Weiner HL. Pediatric intramedullary spinal cord tumors: special considerations. Journal of neuro-oncology. 2000;47(3):225–30.PubMedCrossRefGoogle Scholar
  145. 145.
    Traul DE, Shaffrey ME, Schiff D. Part I: spinal-cord neoplasms-intradural neoplasms. Lancet Oncol. 2007;8(1):35–45.  https://doi.org/10.1016/S1470-2045(06)71009-9.PubMedCrossRefGoogle Scholar
  146. 146.
    Epstein F, Epstein N. Surgical management of holocord intramedullary spinal cord astrocytomas in children. J Neurosurg. 1981;54(6):829–32.  https://doi.org/10.3171/jns.1981.54.6.0829.PubMedCrossRefGoogle Scholar
  147. 147.
    Pagni CA, Canavero S, Gaidolfi E. Intramedullary "holocord" oligodendroglioma: case report. Acta Neurochir (Wien). 1991;113(1-2):96–9.CrossRefGoogle Scholar
  148. 148.
    Vles JS, Grubben CP, van Ooy A, Weil EH. Holocord astrocytomas in childhood. Clinical neurology and neurosurgery. 1990;92(4):361–4.PubMedCrossRefGoogle Scholar
  149. 149.
    Chacko AG, Chandy MJ. Favorable outcome after radical excision of a 'Holocord' astrocytoma. Clinical neurology and neurosurgery. 2000;102(4):240–2.PubMedCrossRefGoogle Scholar
  150. 150.
    Benzel EC, Mirfarkhraee M, Hadden T, Fowler M. Holocord astrocytoma: a two-staged operative approach. Spine. 1987;12(8):746–9.PubMedCrossRefGoogle Scholar
  151. 151.
    Schittenhelm J, Ebner FH, Tatagiba M, Wolff M, Nagele T, Meyermann R, Mittelbronn M. Holocord pilocytic astrocytoma--case report and review of the literature. Clinical neurology and neurosurgery. 2009;111(2):203–7.  https://doi.org/10.1016/j.clineuro.2008.09.014.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nir Shimony
    • 1
  • Brooks Osburn
    • 2
  • Sara Hartnett
    • 2
  • Mari Groves
    • 3
    • 4
  • George I. Jallo
    • 1
    • 4
    Email author
  1. 1.Institute for Brain Protection Sciences, Johns Hopkins All Children’s HospitalSt. PetersburgUSA
  2. 2.Department of Neurosurgery and Brain RepairUniversity of South FloridaTampaUSA
  3. 3.Department of NeurosurgeryUniversity of Maryland School of MedicineBaltimoreUSA
  4. 4.Department of NeurosurgeryJohns Hopkins School of Medicine and HospitalBaltimoreUSA

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