Light-Emitting Diodes for Healthcare and Well-being

  • Ying Gu
  • Haixia Qiu
  • Ying Wang
  • Naiyan Huang
  • Timon Cheng-Yi Liu
Part of the Solid State Lighting Technology and Application Series book series (SSLTA, volume 4)


With the rapid development of semiconductors both in materials and technologies in recent years, LED has taken on a new look: higher luminous intensity, more stable peak wavelength, narrower half-wave bandwidth, better monochromaticity and orientation, and a nearly full coverage of the whole spectrum. In addition, LED devices are small in size, easy to operate and carry, and low in cost. They can be used to form complicated geometric figures so as to form point, line, and surface light sources and even flexible soft light source adaptable to the shape of a treatment area to realize evener illumination. For these reasons, LED light sources are now more and more popular in clinical practice. In this chapter, the mechanisms and indications of LED phototherapy and the status quo of the research on and development of LED phototherapy devices are introduced.


Light-emitting diodes Light source Photobiomodulation Low-level light therapy Photodynamic therapy LED phototherapy LED device Mechanism Application 


  1. 1.
    H. Chung et al., The nuts and bolts of low-level laser (light) therapy. Ann. Biomed. Eng. 40(2), 516–533 (2012)CrossRefGoogle Scholar
  2. 2.
    W. Cannon, The Wisdom of the Body (W. W. Norton, New York, 1932)CrossRefGoogle Scholar
  3. 3.
    T.C.Y. Liu et al., Homeostatic photobiomodulation. Front. Optoelectron. China 2(1), 1–8 (2009)CrossRefGoogle Scholar
  4. 4.
    T.C.Y. Liu et al., Photobiomodulation on stress. Int. J. Photoenergy 2012, 628649 (2012). Scholar
  5. 5.
    T.C.Y. Liu et al., Microenvironment dependent photobiomodulation on function-specific signal transduction pathways. Int. J. Photoenergy 2014, 904304 (2014). Scholar
  6. 6.
    T.C.Y. Liu, Y.Y. Kang, Functional photobiomodulation. Photomed. Laser Surg. 32(9), 479–480 (2014)CrossRefGoogle Scholar
  7. 7.
    T.C.Y. Liu et al., The mitochondrial Na+/Ca2+ exchanger is necessary but not sufficient for Ca2+ homeostasis and viability. Adv. Exp. Med. Biol. 1072, 281–285 (2018)CrossRefGoogle Scholar
  8. 8.
    T.C.Y. Liu et al., Quantitative biology of exercise-induced signal transduction pathways. Adv. Exp. Med. Biol. 977, 419–424 (2017)CrossRefGoogle Scholar
  9. 9.
    C.Y. Liu et al., Self-similarity constant and quantitative difference and their applications in sports science. J. Phys. Educ. 24(6), 72–78 (2017). in ChineseGoogle Scholar
  10. 10.
    M.R. Hamblin, Shining light on the head: photobiomodulation for brain disorders. BBA Clin. 6, 113–124 (2016)CrossRefGoogle Scholar
  11. 11.
    T. Karu, The Science of Low-Power Laser Therapy (Gordon and Breach Science, Amsterdam, 1998)Google Scholar
  12. 12.
    N. Lane, Cell biology - power games. Nature 443(7114), 901–903 (2006)CrossRefGoogle Scholar
  13. 13.
    X.L. Wang et al., Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser. Sci. Rep. 6, 30540 (2016)CrossRefGoogle Scholar
  14. 14.
    M. Huttemann et al., Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease, in Mitochondrial Oxidative Phosphorylation: Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology, vol. 748, (Springer, New York, 2012), pp. 237–264CrossRefGoogle Scholar
  15. 15.
    S.A. Wu et al., Cancer phototherapy via selective photoinactivation of respiratory chain oxidase to trigger a fatal superoxide anion burst. Antioxid. Redox Signal. 20(5), 733–746 (2014)CrossRefGoogle Scholar
  16. 16.
    W. De Haes et al., Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc. Natl. Acad. Sci. U. S. A. 111(24), E2501–E2509 (2014)CrossRefGoogle Scholar
  17. 17.
    C. Yee, W. Yang, S. Hekimi, The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell 157(4), 897–909 (2014)CrossRefGoogle Scholar
  18. 18.
    B. Drew et al., Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284(2), R474–R480 (2003)CrossRefGoogle Scholar
  19. 19.
    L.A. Montoro et al., Infrared LED irradiation photobiomodulation of oxidative stress in human dental pulp cells. Int. Endod. J. 47(8), 747–755 (2014)CrossRefGoogle Scholar
  20. 20.
    G.Y. Luo et al., The effects of low-intensity He-Ne laser irradiation on erythrocyte metabolism. Lasers Med. Sci. 30(9), 2313–2318 (2015)CrossRefGoogle Scholar
  21. 21.
    V.Y. Arshavsky, T.D. Lamb, E.N. Pugh, G proteins and phototransduction. Annu. Rev. Physiol. 64, 153–187 (2002)CrossRefGoogle Scholar
  22. 22.
    S.S. Campbell, P.J. Murphy, Extraocular circadian phototransduction in humans. Science 279(5349), 396–399 (1998)CrossRefGoogle Scholar
  23. 23.
    T.C.Y. Liu, Y.Q. Gao, S.H. Liu, Light-cell interaction: quasi-hormone model and time theory. Proc. SPIE 2887 (1996).
  24. 24.
    Liu, T. C. Y., et al., Membrane mechanism of low intensity laser biostimulation on a cell. Simunovic Z. Lasers in Medicine, Surgery and Dentistry. Zagreb: European Medical Laser Association. 2003: p. 83–105Google Scholar
  25. 25.
    R. Duan et al., Signal transduction pathways involved in low intensity He-Ne laser-induced respiratory burst in bovine neutrophils: a potential mechanism of low intensity laser biostimulation. Lasers Surg. Med. 29(2), 174–178 (2001)CrossRefGoogle Scholar
  26. 26.
    S.N. Wu, D. Xing, Intracellular signaling cascades following light irradiation. Laser Photonics Rev. 8(1), 115–130 (2014)CrossRefGoogle Scholar
  27. 27.
    L.R. Braathen et al., Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005. J. Am. Acad. Dermatol. 56(1), 125–143 (2007)CrossRefGoogle Scholar
  28. 28.
    M.H. Abdel-Kader, Photodynamic Therapy. From Theory to Application (Springer, New York, 2014), pp. 102–103CrossRefGoogle Scholar
  29. 29.
    D.F. Chen et al., Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence. J. Innov. Opt. Health Sci. 9(6), 1650019 (2016)CrossRefGoogle Scholar
  30. 30.
    J.S. Dysart, M.S. Patterson, Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in vitro. Phys. Med. Biol. 50(11), 2597–2616 (2005)CrossRefGoogle Scholar
  31. 31.
    V.H. Fingar et al., The role of microvascular damage in photodynamic therapy: the effect of treatment on vessel constriction, permeability, and leukocyte adhesion. Cancer Res. 52(18), 4914–4921 (1992)Google Scholar
  32. 32.
    M. Firczuk, D. Nowis, J. Golab, PDT-induced inflammatory and host responses. Photochem. Photobiol. Sci. 10(5), 653–663 (2011)CrossRefGoogle Scholar
  33. 33.
    H.X. Qiu et al., Twenty years of clinical experience with a new modality of vascular-targeted photodynamic therapy for port wine stains. Dermatol. Surg. 37(11), 1603–1610 (2011)CrossRefGoogle Scholar
  34. 34.
    U. Schmidt-Erfurth, T. Hasan, Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration. Surv. Ophthalmol. 45(3), 195–214 (2000)CrossRefGoogle Scholar
  35. 35.
    H.X. Qiu et al., Vascular targeted photodynamic therapy for bleeding gastrointestinal mucosal vascular lesions: a preliminary study. Photodiagn. Photodyn. Ther. 9(2), 109–117 (2012)CrossRefGoogle Scholar
  36. 36.
    P. Kumar, D. Chawla, A. Deorari, Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates. Cochrane Database Syst. Rev. (12), CD007969 (2011).
  37. 37.
    M. Mohammadizadeh, F.K. Eliadarani, Z. Badiei, Is the light-emitting diode a better light source than fluorescent tube for phototherapy of neonatal jaundice in preterm infants? Adv. Biomed. Res. 1(1), 51 (2012)CrossRefGoogle Scholar
  38. 38.
    P.H. Desan et al., A controlled trial of the litebook light-emitting diode (LED) light therapy device for treatment of seasonal affective disorder (SAD). BMC Psychiatry 7(1), 38 (2007)CrossRefGoogle Scholar
  39. 39.
    F. Schiffer et al., Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety. Behav. Brain Funct. 5(1), 46 (2009)CrossRefGoogle Scholar
  40. 40.
    M.A. Naeser et al., Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study. J. Neurotrauma 31(11), 1008–1017 (2014)CrossRefGoogle Scholar
  41. 41.
    G. Glickman, B. Byrne, C. Pineda, et al., Light therapy for seasonal affective disorder with blue narrow-band light-emitting diodes (LEDs). Biol. Psychiatry 59(6), 502–507 (2006)CrossRefGoogle Scholar
  42. 42.
    A.S. Salgado et al., The effects of transcranial LED therapy (TCLT) on cerebral blood flow in the elderly women. Lasers Med. Sci. 30(1), 339–346 (2015)CrossRefGoogle Scholar
  43. 43.
    H. Nawashiro, K. Wada, K. Nakai, et al., Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state. Photomed. Laser Surg. 30(4), 231–233 (2012)CrossRefGoogle Scholar
  44. 44.
    S. Dixit et al., Closure of non-healing chronic ulcer in Klippel–Trenaunay syndrome using low-level laser therapy. BMJ Case Rep. 2012, bcr2012006226 (2012). Scholar
  45. 45.
    R. Sutterfield, Light therapy and advanced wound care for a neuropathic plantar ulcer on a Charcot foot. J. Wound Ostomy Continence Nurs. 35(1), 113–115 (2008)CrossRefGoogle Scholar
  46. 46.
    M.A. Trelles, I. Allones, E. Mayo, Er:YAG laser ablation of plantar verrucae with red LED therapy-assisted healing. Photomed. Laser Surg. 24(4), 494–498 (2006)CrossRefGoogle Scholar
  47. 47.
    S.Y. Lee, C.E. You, M.Y. Park, Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV. Lasers Surg. Med. 39(2), 180–188 (2007)CrossRefGoogle Scholar
  48. 48.
    D.J. Goldberg, B.A. Russell, Combination blue (415 nm) and red (633 nm) led phototherapy in the treatment of mild to severe acne vulgaris. J. Cosmet. Laser Ther. 8(2), 71–75 (2006)CrossRefGoogle Scholar
  49. 49.
    N. Sadick, A study to determine the effect of combination blue (415 nm) and near-infrared (830 nm) light-emitting diode (led) therapy for moderate acne vulgaris. J. Cosmet. Laser Ther. 11(2), 125–128 (2009)CrossRefGoogle Scholar
  50. 50.
    L.H. de Arruda et al., A prospective, randomized, open and comparative study to evaluate the safety and efficacy of blue light treatment versus a topical benzoyl peroxide 5% formulation in patients with acne grade II and III. An. Bras. Dermatol. 84(5), 463–468 (2009)MathSciNetCrossRefGoogle Scholar
  51. 51.
    L.H. Liu et al., Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients. Photodermatol. Photoimmunol. Photomed. 30(5), 246–353 (2014)CrossRefGoogle Scholar
  52. 52.
    R.A. Weiss et al., Clinical trial of a novel non-thermal led array for reversal of photoaging: clinical, histologic, and surface profilometric results. Lasers Surg. Med. 36(2), 85–91 (2005)MathSciNetCrossRefGoogle Scholar
  53. 53.
    D. Barolet et al., Regulation of skin collagen metabolism in vitro using a pulsed 660 nm led light source: clinical correlation with a single-blinded study. J. Invest. Dermatol. 129(12), 2751–2759 (2009)CrossRefGoogle Scholar
  54. 54.
    S.Y. Lee et al., A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on led phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. J. Photochem. Photobiol. B 88(1), 51–67 (2007)CrossRefGoogle Scholar
  55. 55.
    D. Barolet, A. Boucher, Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: a case series. Lasers Surg. Med. 42(6), 597–601 (2010)CrossRefGoogle Scholar
  56. 56.
    Y.J. Park et al., Prevention of thyroidectomy scars in Asian adults with low-level light therapy. Dermatol. Surg. 42(4), 526–534 (2016)CrossRefGoogle Scholar
  57. 57.
    E.C. Leal-Junior et al., Adjunctive use of combination of super-pulsed laser and light-emitting diodes phototherapy on nonspecific knee pain: double-blinded randomized placebo-controlled trial. Lasers Med. Sci. 29(6), 1839–1847 (2014)CrossRefGoogle Scholar
  58. 58.
    J. Foley et al., 830 nm light-emitting diode (led) phototherapy significantly reduced return-to-play in injured university athletes: a pilot study. Laser Ther. 25(1), 35 (2016)CrossRefGoogle Scholar
  59. 59.
    D. Pariser et al., Topical methyl-aminolevulinate photodynamic therapy using red light-emitting diode light for treatment of multiple actinic keratoses: a randomized, double-blind, placebo-controlled study. J. Am. Acad. Dermatol. 59(4), 569–576 (2008)CrossRefGoogle Scholar
  60. 60.
    C.D. Enk, A. Levi, Low-irradiance red LED traffic lamps as light source in PDT for actinic keratoses. Photodermatol. Photoimmunol. Photomed. 28(6), 332–334 (2012)CrossRefGoogle Scholar
  61. 61.
    X.L. Wang et al., Topical ALA PDT for the treatment of severe acne vulgaris. Photodiagn. Photodyn. Ther. 7(1), 33–38 (2010)CrossRefGoogle Scholar
  62. 62.
    L. Ma et al., Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris. Photodiagn. Photodyn. Ther. 10(4), 583 (2013)CrossRefGoogle Scholar
  63. 63.
    S.Q. Tao et al., Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris. Cell Biochem. Biophys. 73(3), 701–706 (2015)CrossRefGoogle Scholar
  64. 64.
    S.Q. Tao et al., Efficacy of 3.6% topical ALA-PDT for the treatment of severe acne vulgaris. Eur. Rev. Med. Pharmacol. Sci 20(2), 225–231 (2016)Google Scholar
  65. 65.
    B.H. Song et al., Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: a randomized, single-blind, split-face study. J. Am. Acad. Dermatol. 71(4), 764–771 (2014)CrossRefGoogle Scholar
  66. 66.
    E. Christensen et al., Guidelines for practical use of MAL-PDT in non-melanoma skin cancer. J. Eur. Acad. Dermatol. Venereol. 24(5), 505–512 (2010)CrossRefGoogle Scholar
  67. 67.
    A. Čarija et al., Single treatment of low-risk basal cell carcinomas with pulsed dye laser-mediated photodynamic therapy (PDL-PDT) compared with photodynamic therapy (PDT): a controlled, investigator-blinded, intra-individual prospective study. Photodiagn. Photodyn. Ther. 16, 60–65 (2016)CrossRefGoogle Scholar
  68. 68.
    D.P. Leite et al., Effects of photodynamic therapy with blue light and curcumin as mouth rinse for oral disinfection: a randomized controlled trial. Photomed. Laser Surg. 32(11), 627–632 (2014)CrossRefGoogle Scholar
  69. 69.
    M.A. Melo et al., Photodynamic antimicrobial chemotherapy and ultraconservative caries removal linked for management of deep caries lesions. Photodiagn. Photodyn. Ther. 12(4), 581–586 (2015)CrossRefGoogle Scholar
  70. 70.
    C. Mongardini, G.L. Di Tanna, A. Pilloni, Light-activated disinfection using a light-emitting diode lamp in the red spectrum: clinical and microbiological short-term findings on periodontitis patients in maintenance. A randomized controlled split-mouth clinical trial. Lasers Med. Sci. 29(1), 1–8 (2014)CrossRefGoogle Scholar
  71. 71.
    E.G. Mima et al., Comparison of photodynamic therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial. Clin. Microbiol. Infect. 18(10), E380–E388 (2012)CrossRefGoogle Scholar
  72. 72.
    H.J. Vreman, R.J. Wong, D.K. Stevenson, Phototherapy: current methods and future directions. Semin. Perinatol. 28(5), 326–333 (2004)CrossRefGoogle Scholar
  73. 73.
    S. Pfaff et al., Prospective randomized long-term study on the efficacy and safety of UV-free blue light for treating mild psoriasis vulgaris. Dermatology 231(1), 24–34 (2015)CrossRefGoogle Scholar
  74. 74.
    W.S. Kim, R.G. Calderhead, Is light-emitting diode phototherapy (LED-LLLT) really effective? Laser Ther. 20(3), 205–215 (2011)CrossRefGoogle Scholar
  75. 75.
    H.S. Xiang et al., Led is applied to the development of light therapy. Beijing Biomed. Eng. 24(4), 311–315 (2005)MathSciNetGoogle Scholar
  76. 76.
    T. Yan, LED light source is in the application of skin medicine. China Illuminating Society light biology, photochemical application research forum and ecological lighting forum (2013)Google Scholar
  77. 77.
    S.K. Attili, An open pilot study of ambulatory photodynamic therapy using a wearable low-irradiance organic light-emitting diode light source in the treatment of nonmelanoma skin cancer. Br. J. Dermatol. 161(1), 170–173 (2009)CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Ying Gu
    • 1
  • Haixia Qiu
    • 1
  • Ying Wang
    • 1
  • Naiyan Huang
    • 1
  • Timon Cheng-Yi Liu
    • 2
  1. 1.Chinese PLA General HospitalBeijingChina
  2. 2.South China Normal UniversityGuangzhouChina

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