Pain pp 297-299 | Cite as

Alpha-2 Agonists

  • Moheb Gohar
  • Samantha Stamper
  • Ehab FaragEmail author


Alpha-2 adrenergic agonists have various applications in the different fields of medicine, one of which is pain management. They play a role at the central and peripheral levels to provide analgesia. Their use has been established through various routes to provide analgesia.


α2 agnoists Clonidine Dexmedetomidine 


  1. 1.
    Afonso J, Reis F. Dexmedetomidine: current role in anesthesia and intensive care. Rev Bras Anestesiol. 2012;62(1):118–33.Google Scholar
  2. 2.
    Gertler R, Brown HC, Mitchell DH, Silvius EN. Dexmedetomidine: a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent). 2001;14(1):13–21.CrossRefGoogle Scholar
  3. 3.
    Glick DB. The autonomic nervous system, Miller’s anesthesia. 8th ed., Chapter 16. Philadelphia: W B Saunders Company; 2015. pp. 368–369. ISBN: 978-0-7020-5283-5, 978-0-323-28011-2.Google Scholar
  4. 4.
    Chan AK, Cheung CW, Chong YK. Alpha-2 agonists in acute pain management. Expert Opin Pharmacother. 2010;11(17):2849–68. Epub 2010 Aug 13.Google Scholar
  5. 5.
    Muzyk AJ, Fowler JA, Norwood DK, Chilipko A. Role of α2-agonists in the treatment of acute alcohol withdrawal. Ann Pharmacother. 2011;45(5):649–57. Epub 2011 Apr 26.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Cleveland Clinic FoundationMayfield HeightsUSA
  2. 2.Cleveland Clinic FoundationClevelandUSA
  3. 3.Cleveland Clinic FoundationSolonUSA

Personalised recommendations