Neuroleptics, or antipsychotics, have limited use in the treatment of pain. Only first generation, or typical antipsychotics, have been evaluated for use in some pain syndromes, with mixed results; second generation, or atypical antipsychotics, have only been primarily looked at in case studies. Antipsychotics work at a variety of receptors, including dopamine, serotonin, alpha adrenergic, muscarinic and histamine receptors. Their antagonist activity at the dopamine and serotonin receptors is thought to contribute to their effects on pain control. Antipsychotics have significant and varying side effects and are not recommended for initial or early treatment of pain.
KeywordsNeuroleptic Antipsychotic Typical Atypical Pain Fibromyalgia Receptors
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