Pain pp 1269-1271 | Cite as

Restless Legs Syndrome

  • Ken P. Ehrhardt
  • Mark R. Jones
  • Alan David KayeEmail author


Restless Legs Syndrome, also known as Willis-Ekbom disease , is a sleeping disorder that produces an urge to move one’s legs, often accompanied by abnormal leg sensations. The International Restless Legs Syndrome Study Group developed a series of five standards in 2012. Restless Legs Syndrome is common and is associated with multiple risk factors. These risk factors include female gender, chronic renal disease, pregnancy, iron deficiency, anxiety, insomnia, and depression. Treatment for this disorder ranges from behavioral therapy such as mental stimulation, walking or any type of physical exercise to pharmacological therapy, including ropinirole, pramipexole and rotigotine patches, gabapentanoid agents, and opioids, depending on the severity of the disease.


Restless leg syndrome Iron deficiency Ropinirole Pramipexole 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ken P. Ehrhardt
    • 1
  • Mark R. Jones
    • 2
  • Alan David Kaye
    • 1
    Email author
  1. 1.Department of AnesthesiologyLSU Health Science CenterNew OrleansUSA
  2. 2.Harvard Medical School, Department of AnesthesiologyCritical Care and Pain Medicine, Beth Israel Deaconess Medical CenterBostonUSA

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