Pain pp 1207-1210 | Cite as


  • Emily Bouley
  • Mark R. Jones
  • Alan David KayeEmail author


Osteoarthritis is the most common form of arthritis and continues to increase in prevalence with the aging population. This degenerative disease process involves a complex interaction of several factors including inflammation, genetics, joint structure, mechanical stresses, and cellular processes. This chapter discusses the fundamental pathogenesis, clinical findings, and treatment modalities of osteoarthritis.


Osteoarthritis Degenerative joint disease Joint inflammation Cartilage damage Synovitis 


  1. 1.
    Lane NE, Brandt K, Hawker G, Peeva E, Schreyer E, Tsuji W, et al. OARSI-FDA initiative: defining the disease state of osteoarthritis. Osteoarthr Cartil. 2011;19(5):478–82.CrossRefGoogle Scholar
  2. 2.
    Loeser RF. Osteoarthritis year in review 2013: biology. Osteoarthr Cartil. 2013;21(10):1436–42.CrossRefGoogle Scholar
  3. 3.
    Liu-Bryan R, Terkeltaub R. Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol. 2015;11(1):35–44.CrossRefGoogle Scholar
  4. 4.
    McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil. 2014;22(3):363–88.CrossRefGoogle Scholar
  5. 5.
    Hunter DJ. Focusing osteoarthritis management on modifiable risk factors and future therapeutic prospects. Ther Adv Musculoskelet Dis. 2009;1(1):35–47.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Emily Bouley
    • 1
  • Mark R. Jones
    • 1
  • Alan David Kaye
    • 2
    Email author
  1. 1.Department of AnesthesiologyBeth Israel Deaconess Medical CenterBostonUSA
  2. 2.Louisiana State University Health Science CenterNew OrleansUSA

Personalised recommendations