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Pain pp 1127-1130 | Cite as

Biopharmacologic and Neurophysiologic Basis of Addiction

  • Randall T. BrownEmail author
Chapter

Abstract

Addiction, or “substance use disorder (SUD),” is characterized by maladaptive substance use that is associated with adverse consequences in term of mental, physical, and social functioning. The state of addiction is associated with predictable alterations of central nervous system (CNS) function and neurobiology that, in turn, are predictive of behavioral patterns and functional declines. As such, SUDs are accurately characterized as a chronic relapsing disease of the brain.

Keywords

Substance use disorder Addiction Neurobiology 

References

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    Volkow N, Baler R. Drug addiction: the neurobiology of behavior. In: Herron AJ, Brennan TK, editors. ASAM Essentials of Addiction Medicine. 2nd ed; 2015.Google Scholar
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    American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5®). Washington, DC: American Psychiatric Pub. 5th ed; 2013.Google Scholar
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    Herron AJ, Brennan TK, editors. ASAM Essentials of Addiction Medicine: Lippincott, Williams, and Wilkins, Philadelphia, PA. 2015.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Family Medicine and Community HealthUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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