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Pain pp 1013-1017 | Cite as

Local Anesthetics

  • Carrie Schroeder
  • Kristopher SchroederEmail author
Chapter

Abstract

Local anesthetics block nerve conduction via blockade of voltage-gated sodium channels. The physiochemical properties of the individual drugs lead to variability in individual drug potency, onset, and duration. Systemic toxicity can occur via drug overdose, intravenous dosing, or impaired drug elimination. Clinical signs of toxicity can be manifested via the central nervous system and may progress to the cardiovascular system. Treatment of local anesthetic systemic toxicity (LAST) is directed at supportive treatment and administration of lipid emulsion.

Keywords

Pharmacology Local anesthetics Regional anesthesia 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Surgical SciencesUniversity of Wisconsin School of Veterinary MedicineMadisonUSA
  2. 2.Department of Anesthesiology, University of Wisconsin School of Medicine and Public HealthMadisonUSA

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