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Pain pp 811-815 | Cite as

Peripheral and Central Mechanisms of Visceral Pain Modulation

  • Matthew B. Novitch
  • Mark R. Jones
  • Alan David KayeEmail author
Chapter

Abstract

Visceral pain is a negatively perceived sensation conveyed by organ systems due to stretch, inflammation, ischemia, and other mechanisms of organ damage. This experience can be modulated by central acting mechanisms which can inhibit ascending pain signals, or by peripherally acting mechanisms such as local peptide release. Understanding the mechanisms of visceral pain and its modulation are vital in the creation and application of therapies which reduce the response to painful stimuli. This chapter covers several of these well-studied processes and their role in the perception of pain.

Keywords

Visceral Modulation Descending Ascending Central Peripheral Agonist Hyperalgesia 

References

  1. 1.
    Raskin NH, Hosobuchi Y, Lamb S. Headache may arise from perturbation of brain. Headache. 1987;27(8):416–20. http://www.ncbi.nlm.nih.gov/pubmed/3667258. Accessed 27 Sept 2017.CrossRefGoogle Scholar
  2. 2.
    Heinricher MM, Morgan MM, Fields HL. Direct and indirect actions of morphine on medullary neurons that modulate nociception. Neuroscience. 1992;48(3):533–43. http://www.ncbi.nlm.nih.gov/pubmed/1603332. Accessed 27 Sept 2017.CrossRefGoogle Scholar
  3. 3.
    Cui M, Feng Y, McAdoo DJ, Willis WD. Periaqueductal gray stimulation-induced inhibition of nociceptive dorsal horn neurons in rats is associated with the release of norepinephrine, serotonin, and amino acids. J Pharmacol Exp Ther. 1999;289(2):868–76. http://www.ncbi.nlm.nih.gov/pubmed/10215665. Accessed 27 Sept 2017.PubMedGoogle Scholar
  4. 4.
    King CD, Wong F, Currie T, Mauderli AP, Fillingim RB, Riley JL. Deficiency in endogenous modulation of prolonged heat pain in patients with irritable bowel syndrome and temporomandibular disorder. Pain. 2009;143(3):172–8.CrossRefGoogle Scholar
  5. 5.
    Stein C, Clark JD, Oh U, et al. Peripheral mechanisms of pain and analgesia. Brain Res Rev. 2009;60(1):90–113.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Matthew B. Novitch
    • 1
  • Mark R. Jones
    • 2
  • Alan David Kaye
    • 3
    Email author
  1. 1.Medical College of WisconsinWausauUSA
  2. 2.Department of Anesthesiology, Harvard Medical SchoolBeth Israel Deaconess Medical CenterBostonUSA
  3. 3.LSUHSC Department of AnesthesiologyNew OrleansUSA

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