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Models of Rate and Phase Coding of Place Cells in Hippocampal Microcircuits

  • Vassilis CutsuridisEmail author
Chapter
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI)

Abstract

Place cells are neurons that fire when the animal occupies a specific location within its environment (O’Keefe and Nadel 1978). As different place cells have different place fields (locations where they fire), they are thought to provide a cognitive map for the rat. Furthermore, place cells are speed-dependent oscillators, as their oscillation frequency is determined by the animal’s traveling speed (Buzsaki 2011). Their firing rates and phases also change with respect to LFP theta (O’Keefe and Recce 1993; Johnson and Redish 2007; Skaggs etal. 1996; Wilson and McNaughton 1993). Theta oscillations (4–10 Hz) are observed during animal exploration and rapid eye movement sleep (Buzsaki 2002). During exploration (Fig. 1 top) hippocampal place cells’ firing rate increases as the position of the rat in the place field increases, reaching a maximal value just after the middle of the place field and beyond this point it decreases again (Fig. 1 medium; Harris etal. 2002; Mehta etal. 2002). Place cells have also been shown to systematically shift their phase of firing to earlier phases of the theta rhythm as the animal transverses the place field (a phenomenon known as theta phase precession) (Fig. 1 bottom; O’Keefe and Recce 1993; Skaggs etal. 1996).

Keywords

Navigation Place cell Hippocampus Cognitive map Phase precession Rate coding Theta rhythm Inhibition Synaptic plasticity 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.School of Computer ScienceUniversity of LincolnLincolnUK

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