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Aggregation-Induced Emission Luminogens for Biomedical Applications

  • Dan DingEmail author
Chapter

Abstract

In recent years, luminogens with aggregation-induced emission (AIE) feature have attracted a great deal of attention, and been used in many high-tech fields. One important application is the biological diagnostics and therapeutics. Thus far, AIE luminogens (AIEgens) have been successfully utilized for in vitro/in vivo imaging and therapy, which show excellent performance and great promise. AIEgens have several notable characteristics, such as high brightness, large Stokes shift, marked photostability, and good biocompatibility, making them very suitable for biomedical applications. In this chapter, the recent development of AIEgens as biological agents is summarized, including the in vivo imaging with AIE nanoparticles, activable probes with special turn-on signature, near-infrared AIEgens for high-resolution imaging, theranostic systems combining diagnostic with therapeutic capabilities, and emerging multi-modality platforms. The future perspectives of AIEgens for biomedical applications are also discussed in this chapter.

Keywords

Aggregation-induced emission Biomedical application Nanoparticle Activable probe Near-infrared Theranostics Multi-modality 

Notes

Acknowledgment

The authors gratefully acknowledge financial support provided by the National Natural Science Foundation of China (51622305).

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life SciencesNankai UniversityTianjinChina

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