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Equipment and Instrumentation for Radiopharmaceutical Chemistry

  • Stephen Thompson
  • Peter J. H. ScottEmail author
Chapter

Abstract

Radiochemistry facilities in both academic medical centers and commercial nuclear pharmacies consist of technologically advanced laboratories paired with sophisticated imaging and data analysis suites. These units are staffed by multidisciplinary teams of basic scientists, clinicians, technologists, staff scientists, and students and are equipped with state-of-the-art instruments for the daily production of radiopharmaceuticals as well as the performance of preclinical and clinical nuclear imaging and targeted radiotherapy experiments. In this chapter, we will use the lens of positron emission tomography (PET) to provide an overview of the major instrumentation and equipment needed to take a radiopharmaceutical from bench-to-bedside in a manner that is compliant with all pertinent regulations. We also turn our eyes to the future, imagining what the PET Center of tomorrow will look like once all the equipment is connected through the Internet of Things (IoT).

Keywords

Positron emission tomography, PET, radiochemistry Automation Miniaturized quality control Internet of Things 

Notes

Acknowledgments

Financial support of this work from the US DOE (DE-SC0012484) is gratefully acknowledged. The authors declare no competing financial interest.

References

  1. 1.
    Schwarz SW, Dick D, VanBrocklin HF, Hoffman JM. Regulatory Requirements for PETdrug production. J Nucl Med. 2014;55(7):1132–7.CrossRefGoogle Scholar
  2. 2.
    Thompson S, Kilbourn MR, Scott PJH. Radiochemistry, PET imaging, and the Internet of Chemical Things. ACS Cent Sci. 2016;24(2):497–505.CrossRefGoogle Scholar
  3. 3.
    Rutherford E, Geiger H. An electrical method of counting the number of α -particles from radio-active substances. Proc R SocLond A. 1908;81(546):141–61.CrossRefGoogle Scholar
  4. 4.
    Geiger H, Müller W. ElektronenzählrohrzurMessungschwächsterAktivitäten. Naturwissenschaften. 1928;16(31):617–8.CrossRefGoogle Scholar
  5. 5.
    Xiao D. Fundamental theory of Townsend discharge. In: Gas discharge and gas insulation. In: Energy and environment research in China, vol. 6. Berlin/Heidelberg: Springer; 2016. p. 47–88.Google Scholar
  6. 6.
    Lawrence, Ernest O. Method and apparatus for the acceleration of ions. US Patent 1,948,384; 1934.Google Scholar
  7. 7.
    Holland JP, Sheh Y, Lewi JS. Standardized methods for the production of high specific-activity zirconium-89. Nucl Med Biol. 2009;36(7):729–39.CrossRefGoogle Scholar
  8. 8.
    Pandey MK, Byrne JF, Jiang H, Packard AB, DeGrado TR. Cyclotron production of 68Ga via the 68Zn(p,n)68Ga reaction in aqueous solution. Am J Nucl Med Mol Imaging. 2014;4(4):303–10.PubMedPubMedCentralGoogle Scholar
  9. 9.
    Fani M, André JP, Maecke HR. 68Ga-PET: a powerful generator-based alternative to cyclotron-based PET radiopharmaceuticals. Contrast Media Mol Imaging. 2008;3(2):67–77.CrossRefGoogle Scholar
  10. 10.
    Brodack JW, Kilbourn MR, Welch MJ, Katzenellenbogen J. Automated production of several positron-emitting radiopharmaceuticals using a single laboratory robot. Int J ApplInstrum A. 1988;39(7):689–98.Google Scholar
  11. 11.
    Pascali G, Watts P, Salvadori PA. Microfluidics in radiopharmaceutical chemistry. Nucl Med Biol. 2013;40(6):776–87.CrossRefGoogle Scholar
  12. 12.
    Vallabhajosula S. Quality control of PET radiopharmaceuticals. In: Molecular imaging. Berlin/Heidelberg: Springer; 2009. p. 197–204.CrossRefGoogle Scholar
  13. 13.
    Saha GB. Gas-filled detectors. In: Physics and radiobiology of nuclear medicine. 4th ed. New York: Springer; 2013. p. 79–90.CrossRefGoogle Scholar
  14. 14.
    Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, et al. A combined PET/CT tomograph for clinical oncology. J Nucl Med. 2000;41(8):1369–79.PubMedGoogle Scholar
  15. 15.
    Boss A, Bisdas S, Kolb A, Hofmann M, Ernemann U, Claussen CD, Pfannenberg C, Pichler BJ, Reimold M, Stegger L. Hybrid PET/MRI of intercranial masses: Initial experiences and comparison to PET/CT. J Nucl Med. 2010;51(8):1198–205.CrossRefGoogle Scholar
  16. 16.
    Ashton K. That ‘Internet of Things’ thing, 22 Jun 2009. RFID J. http://www.rfidjournal.com/articles/view?4986. Accessed 5 Nov 2017.
  17. 17.
    Ungoed-Thomas J, Henry R, Gadher D. Cyber-attack guides promoted on YouTube. The Sunday Times [Online], 14 May 2017. https://www.thetimes.co.uk/article/cyber-attack-guides-promoted-on-youtube-972s0hh2c. Accessed 5 Nov 2017.
  18. 18.
    U.S. Food and Drug Administration. Vulnerabilities of HospiraLifeCare PCA3 and PCA5 infusion pump systems: FDA safety communication, 13 May 2015. http://wayback.archive-it.org/7993/20170722144742/, https://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm446809.htm. Accessed 5 Nov 2017.
  19. 19.
    Prodhan G. Siemens to update medical scanner software to deal with security bugs. Reuters [Online], 7 Aug 2017. https://www.reuters.com/article/siemens-healthcare-cyber-idUSL1N1KT0WZ. Accessed 14 Jun 2018.

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of RadiologyUniversity of MichiganAnn ArborUSA

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