Recent Development in Omics Studies

  • Wan Mohd AizatEmail author
  • Ismanizan Ismail
  • Normah Mohd Noor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1102)


The central dogma of molecular biology (DNA, RNA, protein and metabolite) has engraved our understanding of genetics in all living organisms. While the concept has been embraced for many decades, the development of high-throughput technologies particularly omics (genomics, transcriptomics, proteomics and metabolomics) has revolutionised the field to incorporate big data analysis including bioinformatics and systems biology as well as synthetic biology area. These omics approaches as well as systems and synthetic biology areas are now increasingly popular as seen by the growing numbers of publication throughout the years. Several journals which have published most of these related fields are also listed in this chapter to overview their impact and target journals.


Genomics Metabolomics Molecular biology Proteomics Systems biology Transcriptomics 


  1. 1.
    Weaver RF (2012) Molecular biology. McGraw Hill, New YorkGoogle Scholar
  2. 2.
    Guzman I, Hamby S, Romero J, Bosland PW, O’Connell MA (2010) Variability of carotenoid biosynthesis in orange colored Capsicum spp. Plant Sci 179:49–59CrossRefGoogle Scholar
  3. 3.
    Ha SH, Kim JB, Park JS, Lee SW, Cho KJ (2007) A comparison of the carotenoid accumulation in Capsicum varieties that show different ripening colours: deletion of the capsanthin-capsorubin synthase gene is not a prerequisite for the formation of a yellow pepper. J Exp Bot 58:3135–3144CrossRefGoogle Scholar
  4. 4.
    Voit EO (2012) A first course in systems biology. Garland Science, New YorkGoogle Scholar
  5. 5.
  6. 6.
    Ignacimuthu S (2005) Basic bioinformatics. Alpha Science Int’l Ltd., OxfordGoogle Scholar
  7. 7.
    Twyman RM (2013) Principles of proteomics. Garland Science, AbingdonGoogle Scholar
  8. 8.
    Baginsky S (2009) Plant proteomics: concepts, applications, and novel strategies for data interpretation. Mass Spectrom Rev 28:93–120CrossRefGoogle Scholar
  9. 9.
    Domon B, Aebersold R (2006) Mass spectrometry and protein analysis. Science 312:212–217CrossRefGoogle Scholar
  10. 10.
    Domon B, Aebersold R (2010) Options and considerations when selecting a quantitative proteomics strategy. Nat Biotechnol 28:710–721CrossRefGoogle Scholar
  11. 11.
    Dettmer K, Aronov PA, Hammock BD (2007) Mass spectrometry-based metabolomics. Mass Spectrom Rev 26:51–78CrossRefGoogle Scholar
  12. 12.
    Patti GJ, Yanes O, Siuzdak G (2012) Innovation: metabolomics: the apogee of the omics trilogy. Nature 13:263Google Scholar
  13. 13.
    Villas-Bôas SG, Mas S, Åkesson M, Smedsgaard J, Nielsen J (2005) Mass spectrometry in metabolome analysis. Mass Spectrom Rev 24:613–646CrossRefGoogle Scholar
  14. 14.
    Joyce AR, Palsson BØ (2006) The model organism as a system: integrating ‘omics’ data sets. Nature 7:198–210CrossRefGoogle Scholar
  15. 15.
    Mochida K, Shinozaki K (2011) Advances in omics and bioinformatics tools for systems analyses of plant functions. Plant Cell Physiol 52:2017–2038CrossRefGoogle Scholar
  16. 16.
    Gatherer D (2010) So what do we really mean when we say that systems biology is holistic? BMC Syst Biol 4:1–22CrossRefGoogle Scholar
  17. 17.
    Ideker T, Galitski T, Hood L (2001) A new approach to decoding life: systems biology. Annu Rev Genomics Hum Genet 2:343–372CrossRefGoogle Scholar
  18. 18.
    Kitano H (2002) Systems biology: a brief overview. Science 295:1662–1664CrossRefGoogle Scholar
  19. 19.
    Chubukov V, Mukhopadhyay A, Petzold CJ, Keasling JD, Martín HG (2016) Synthetic and systems biology for microbial production of commodity chemicals. Nature 2:16009Google Scholar
  20. 20.
    Cameron DE, Bashor CJ, Collins JJ (2014) A brief history of synthetic biology. Nat Rev Microbiol 12:381–390CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Wan Mohd Aizat
    • 1
    Email author
  • Ismanizan Ismail
    • 1
  • Normah Mohd Noor
    • 1
  1. 1.Institute of Systems BiologyUniversiti Kebangsaan Malaysia (UKM)BangiMalaysia

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