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Endometrial Carcinoma

  • Tricia A. Murdock
  • Emanuela F. T. Veras
  • Robert J. Kurman
  • Michael T. Mazur
Chapter

Abstract

Endometrial carcinoma is the 4th most common cancer for American women and the most common malignant tumor of the female genital tract. In the United States in 2015, there were 54,644 new cases and 10,096 deaths resulting from this neoplasm. Black women have a much higher rate of mortality when compared to white women. Although most endometrial carcinomas that are diagnosed at early stages have an excellent survival rate, this neoplasm represents a biologically and morphologically diverse group of tumors, with differing pathogenesis, behavior, and prognosis. These tumors were grouped into two types based on clinicopathologic features designated “Type I and Type II”. This grouping was helpful in understanding the pathogenesis of endometrial cancer, but it is important to understand that this is not a histopathologic classification. The prototypic Type I tumor is the usual type of endometrioid carcinoma, and the prototypic Type II tumor is serous carcinoma.

Keywords

Endometrial carcinoma Malignant endometrial neoplasms FIGO grading of endometrial carcinoma Hereditary nonpolyposis colorectal cancer (Lynch syndrome) Cowden syndrome Endometrioid carcinoma variants Endometrial carcinoma mimics 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Tricia A. Murdock
    • 1
  • Emanuela F. T. Veras
    • 1
  • Robert J. Kurman
    • 1
  • Michael T. Mazur
    • 2
  1. 1.Department of PathologyThe Johns Hopkins HospitalBaltimoreUSA
  2. 2.Department of Pathology and Laboratory MedicineState University of New York Upstate Medical UniversitySyracuseUSA

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