Chronic Hepatitis B

  • Lindsay Meurer
  • Anthony Post


Hepatitis B (HBV) is a viral infection of the liver and a common cause of chronic liver disease worldwide. An estimated 240 million people are affected by chronic hepatitis B (CHB) infection globally. In the United States, 850,000 to 2.2 million are estimated to be living with HBV. Screening and vaccination efforts have been globally implemented to reduce the burden of disease. This chapter will focus on the diagnosis and management of CHB.


Chronic liver disease HBsAg Cirrhosis Nucleotide/side analogues Pegylated interferon-alpha 

Further Reading

  1. 1.
    Abara WE, Qaseem A, Schillie S, et al. Hepatitis B vaccination, screening, and linkage to care: best practice advice from the American College of Physicians and the Centers for Disease Control and Prevention. Ann Intern Med. 2017;167:794.CrossRefGoogle Scholar
  2. 2.
    Dienstag JL, Hepatitis B. Virus infection. N Engl J Med. 2008;359:1486–500. Scholar
  3. 3.
    European Association for the Study of Liver Disease (EASL) 2017 clinical practice guidelines on the management of hepatitis B virus infection. J Hepatol. 2017;67:370–98.Google Scholar
  4. 4.
    Sundaram V, Kowdley K. Management of chronic hepatitis B infection. BMJ. 2015;351:h4263.CrossRefGoogle Scholar
  5. 5.
    Terrault, et al. American Association for the Study of Liver Disease (AASLD) guidelines for treatment of chronic hepatitis B. Hepatology. 2016;63:261–83.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.University Hospitals Cleveland Medical, Center Case Western Reserve UniversityClevelandUSA
  2. 2.Division of Gastroenterology and Liver DiseaseUniversity Hospitals Cleveland Medical Center, Case Western Reserve UniversityClevelandUSA

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