Hepatorenal Syndrome

  • Yumi AndoEmail author
  • Joseph Ahn


This chapter discusses key distinguishing features of hepatorenal syndrome from other etiologies of kidney injury. The pathophysiology as it is currently understood, as well as best treatment options based on clinical evidence, is described. An emphasis is placed on early diagnosis and treatment. Due to the poor prognosis despite maximal medical therapy, referral for liver transplantation should be initiated.


Portal hypertension Ascites Terlipressin Norepinephrine Sympathetic nervous system Vasopressin Renin-angiotensin-aldosterone system 

Further Reading

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    Allegretti AS, et al. Prognosis of patients with cirrhosis and AKI who initiate RRT. Clin J Am Soc Nephrol. 2018;13(1):16–25.CrossRefGoogle Scholar
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    Gines A, et al. Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites. Gastroenterology. 1993;105(1):229–36.CrossRefGoogle Scholar
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    Gluud L, et al. Terlipressin for hepatorenal syndrome. Cochrane Database Syst Rev. 2012;12(9):CD005162.Google Scholar
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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Medicine, Division of Gastroenterology and HepatologyOregon Health and Science UniversityPortlandUSA

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