Acute Alcoholic Hepatitis

  • Sasan Sakiani
  • Arthur McCulloughEmail author


Alcohol-induced liver disease is the leading cause of chronic liver disease worldwide and remains the second most common cause of cirrhosis in the United States. Heavy alcohol use, which is defined by more than three drinks per day for men and more than two drinks per day for women for over 5 years, can lead to a broad range of chronic liver diseases, including steatosis (60–100% of patients), steatohepatitis and fibrosis (20–40% of patients), and eventually cirrhosis (10–20% of patients) and hepatocellular carcinoma (3–10%). Acute alcoholic hepatitis (AH) is a clinical diagnosis that is based on the development of jaundice and hepatocellular injury that occurs in 35–40% of patients with heavy alcohol use and has been associated with 20–50% mortality in untreated patients. In this chapter, we describe a case of a patient presenting with severe AH. We discuss diagnosis, prognosis, treatment options, and outcomes.


Acute alcoholic hepatitis Alcoholic hepatitis Alcoholic liver disease Corticosteroids Maddrey discriminant function MELD score Liver transplant 

Further Reading

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Gastroenterology and HepatologyDigestive Disease Institute, Cleveland ClinicClevelandUSA
  2. 2.Lerner College of Medicine at Case Western Reserve UniversityClevelandUSA

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