Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease with a wide range of clinical manifestations. Affected individuals may be asymptomatic with mildly elevated serum aminotransferase levels or may present with acute liver failure. While most common in young women, the disease can occur in men and women of all ages and ethnicities. AIH is the result of a complex interaction of environmental triggers, genetic predisposition, and failure of immune tolerance. Immunosuppression with corticosteroids and other immunomodulator therapies are the cornerstones of treatment. Left untreated, AIH can progress to cirrhosis and is the underlying reason for up to 5% of liver transplants.
KeywordsImmunosuppression Corticosteroids Liver transplantation Serologic testing Liver biopsy Pregnancy