Diagnosis and Management of Gallbladder Cancer

  • Joshua L. Lyons
  • John B. Ammori
  • Jeffrey M. HardacreEmail author


Gallbladder cancer (GC) is a rare malignancy with a high mortality rate. Surgery is the only potentially curative treatment. Presentation can vary however with most cases being diagnosed incidentally on routine pathologic exam after a cholecystectomy done for seemingly benign indications. Clinical symptoms secondary to GC typically indicates advanced disease. Treatment decisions are based upon tumor stage. Incidentally discovered T1a cancers are adequately treated with cholecystectomy. T1b to T3 cancers with no evidence of distant metastatic spread are treated with an extended cholecystectomy, regional lymphadenectomy, and bile duct excision if necessary. In the adjuvant setting, treatment options include various chemoradiation and chemotherapy regimens which emphasize the need for multidisciplinary cancer teams in the treatment of GC.


Gallbladder Gallbladder cancer Extended cholecystectomy Cholecystectomy Biliary tract Malignancy 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Joshua L. Lyons
    • 1
  • John B. Ammori
    • 1
  • Jeffrey M. Hardacre
    • 1
    Email author
  1. 1.Department of SurgeryUniversity Hospitals Cleveland Medical CenterClevelandUSA

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