Recurrent Breast Cancer

  • Zeynep Bostanci
  • Laura Kruper


Patients with breast cancer diagnoses are routinely monitored for local and distant recurrence after initial treatment. Patients are followed with history, including a detailed review of systems and physical examination. Diagnostic imaging studies are selected depending on the type of prior surgical treatment and patient’s symptoms. If a local-regional recurrence is suspected, this is confirmed with a biopsy, and tumor markers including ER, PR, and HER-2 are repeated. Next, it is important to investigate the presence of a distant metastasis. Once the distant disease is ruled out, local-regional recurrence is managed with a combination of surgery, systemic therapies, and radiation depending on the patient characteristics. For this reason, patients with recurrent breast cancer should be managed in a multidisciplinary fashion including surgery, medical oncology, and radiation oncology, with plastic surgery and genetics as necessary for the best outcome.


Breast conservation therapy Neoadjuvant chemotherapy Mastectomy Local recurrence Regional recurrence Chest wall recurrence Whole breast radiation Accelerated partial breast irradiation 


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    NCCN clinical practice guidelines in oncology breast cancer, version 2.2017 [Internet]. 2017 [cited 2017 Sept 3]. Available from:

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Zeynep Bostanci
    • 1
  • Laura Kruper
    • 2
  1. 1.Breast Surgical OncologyIronwood Cancer and Research CentersAvondaleUSA
  2. 2.Breast Surgical Oncology, Department of SurgeryCity of Hope HospitalDuarteUSA

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