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Management of Somatostatinoma

  • Rachel E. Simpson
  • Benjamin C. JamesEmail author
Chapter

Abstract

Somatostatinoma is a very rare neuroendocrine tumor, which results in hypersecretion of somatostatin. Patients may experience hyperglycemia, cholelithiasis, steatorrhea, and hypochlorhydria. Biochemical evaluation may show hyperglycemia, and a fasting somatostatin level over 160 pg/mL favors a diagnosis of somatostatinoma. Cross-sectional imaging and endoscopic ultrasound should be utilized for localization. Most tumors are >2 cm in size and are often located in the head of the pancreas. Many patients will have metastatic disease at the time of diagnosis. Surgical resection should be performed when the tumor is localized and amenable to complete surgical excision. Somatostatin analogs may be used to decrease the severity of symptoms.

Keywords

Hyperglycemia Cholelithiasis Steatorrhea Hypochlorhydria Somatostatin 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of SurgeryIndiana UniversityIndianapolisUSA
  2. 2.Department of SurgeryHarvard Medical SchoolBostonUSA
  3. 3.Department of SurgeryBeth Israel Deaconess Medical CenterBostonUSA

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