Cushing’s Syndrome and Disease

  • Edwina Moore
  • Vikram D. KrishnamurthyEmail author


Cushing’s syndrome and disease are conditions of cortisol excess (hypercortisolism). In Cushing’s syndrome, either one or both of the adrenal glands autonomously hypersecrete cortisol. In Cushing’s disease, a pituitary adenoma hypersecretes adrenocorticotropic hormone (ACTH), which in turn stimulates both adrenal glands to release excess cortisol. Therefore, Cushing’s disease is also known as ACTH-dependent Cushing’s syndrome. It is also important to recognize the paraneoplastic syndrome of ectopic ACTH production from neuroendocrine tumors such as small-cell lung carcinoma.


Cushing’s disease Cortisol Hypercortisolism ACTH Adrenalectomy 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Endocrine SurgeryThe Cleveland ClinicClevelandUSA

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