Oligodendroglial Tumors

  • César R. Lacruz
  • Javier Saénz de Santamaría
  • Ricardo H. Bardales
Part of the Essentials in Cytopathology book series (EICP, volume 13)


Oligodendroglioma represents the second major category of diffuse gliomas, accounting for 3–4% of all primary brain tumors. There are two WHO grades of oligodendroglioma that are significant predictors of survival: grade II or well-differentiated tumors and grade III or anaplastic oligodendroglioma. Frozen sections of oligodendrogliomas almost invariably produce misleading cytoplasmic and nuclear artifacts, which is why the cytologic technique is preferable for intraoperative consultation. This chapter reviews the cytomorphologic features and intraoperative differential diagnosis of oligodendroglioma and anaplastic oligodendroglioma.


Intraoperative brain assessment Cytology Squash preparation Smear preparation Oligodendroglioma Anaplastic oligodendroglioma Oligoastrocytoma Oligodendroglial tumors 

Suggested Reading

  1. Eckel-Passow JE, Lachance DH, Molinaro AM, Kyle M, et al. Glioma groups based on 1p/19q, IDH, and TERT promoter mutations in tumors. N Engl J Med. 2015;372:2499–508.CrossRefGoogle Scholar
  2. Goh SGN, Chuah KL. Role of intraoperative smear cytology in the diagnosis of anaplastic oligodendroglioma. Acta Cytol. 2003;47:293–8.CrossRefGoogle Scholar
  3. Kim YH, Nobusawa S, Mittelbronn M, Paulus W, et al. Molecular classification of low-grade diffuse gliomas. Am J Pathol. 2010;177:2708–14.CrossRefGoogle Scholar
  4. Klysik M, Gavito J, Boman D, Miranda RN, Hanbali F, De Las Casas LE. Intraoperative imprint cytology of central neurocytoma: The great oligodendroglioma mimicker. Diagn Cytopathol. 2010;38:202–7.PubMedGoogle Scholar
  5. Koeller KK, Rushing EJ. From the archives of the AFIP: Oligodendroglioma and its variants: radiologic-pathologic correlations. Radiographics. 2005;25:1669–88.CrossRefGoogle Scholar
  6. Kreiger PA, Okada Y, Simon S, Rorke LB, Louis DN, Golden JA. Losses of chromosomes 1p and 19q are rare in pediatric oligodendrogliomas. Acta Neuropathol (Berl). 2005;109:387–92.CrossRefGoogle Scholar
  7. Mitsuhashi T, Shimizu Y, Ban S, Ogawa F, Matsutani M, Shimizu M, Hirose T. Anaplastic oligodendroglioma. A case report with characteristic cytologic features including minigemistocytes. Acta Cytol. 2007;51:657–60.CrossRefGoogle Scholar
  8. Monabati A, Kumar PV, Roozbehi H, Torabinezhad S. Cytologic findings in metastatic oligodendroglioma. Acta Cytol. 2003;47:702–4.PubMedGoogle Scholar
  9. Nguyen GK, Jonson ES, Mielke BW. Comparative cytomorphology of pituitary adenomas and oligodendrogliomas in intraoperative crush preparations. Acta Cytol. 1992;36:661–7.PubMedGoogle Scholar
  10. Park J-Y, Suh Y-L, Han J. Disembryoplastic neuroepithelial tumor. Features distinguishing it from oligodendroglioma on cytologic squash preparations. Acta Cytol. 2003;47:624–9.CrossRefGoogle Scholar
  11. Sahm F, Reuss D, Koelsche C, Capper D, et al. Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. Acta Neuropath. 2014;128:551–9.CrossRefGoogle Scholar
  12. Watanabe T, Nobusawa S, Kleihues P, Ohgaki H. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol. 2009;174:1149–53.CrossRefGoogle Scholar
  13. Wesseling P, van den Bent M, Perry A. Oligodendroglioma: pathology, molecular mechanisms and markers. Acta Neuropathol. 2015;129:809–27.CrossRefGoogle Scholar
  14. Yan H, Parsons DW, Jin G, McLendon R, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360:765–73.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • César R. Lacruz
    • 1
  • Javier Saénz de Santamaría
    • 2
  • Ricardo H. Bardales
    • 3
  1. 1.Professor of PathologyComplutense University School of MedicineMadridSpain
  2. 2.Professor of PathologyUniversity Hospital Extremadura, Medical SchoolBadajozSpain
  3. 3.Pathologist, Director Ultrasound-guided Fine Needle Aspiration ServiceOutpatient Pathology Associates / Precision PathologySacramentoUSA

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