Nerve Sheath Tumors of the Craniospinal Axis

  • César R. Lacruz
  • Javier Saénz de Santamaría
  • Ricardo H. Bardales
Part of the Essentials in Cytopathology book series (EICP, volume 13)


A large number of neurosurgical specimens originate outside of the central neuraxis proper from the nerve sheath cells of the cranial and spinal nerve roots, the vast majority of which are schwannomas arising in the posterior fossa and spinal canal. Specimens from this tumor are difficult to crush yielding smears with cohesive tissue fragments and few, if any, single cells. This chapter also includes the cytomorphologic features and differential diagnosis of melanotic schwannoma, neurofibroma, malignant peripheral nerve sheath tumor, and ganglioneuroma.


Intraoperative brain assessment Cytology Squash technique Smear technique Schwannoma Cellular schwannoma Melanotic schwannoma Neurofibroma MPNST Ganglioneuroma Neurofibromatosis type 1 Neurofibromatosis type 2 Schwannomatosis Carney complex 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • César R. Lacruz
    • 1
  • Javier Saénz de Santamaría
    • 2
  • Ricardo H. Bardales
    • 3
  1. 1.Professor of PathologyComplutense University School of MedicineMadridSpain
  2. 2.Professor of PathologyUniversity Hospital Extremadura, Medical SchoolBadajozSpain
  3. 3.Pathologist, Director Ultrasound-guided Fine Needle Aspiration ServiceOutpatient Pathology Associates / Precision PathologySacramentoUSA

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