Non-meningothelial Mesenchymal Tumors

  • César R. Lacruz
  • Javier Saénz de Santamaría
  • Ricardo H. Bardales
Part of the Essentials in Cytopathology book series (EICP, volume 13)


CNS mesenchymal, non-meningothelial tumors arise from craniospinal meninges, supporting tissues, vasculature, or surrounding osseous structures, representing the homologous of neoplasms encountered far more frequently in the somatic soft tissues or bones. These neoplasms can occur in patients of any age and may arise anywhere along the neuroaxis and its coverings, with tumors arising in meninges more common than ones originating within CNS parenchyma or in choroid plexus. This chapter primarily emphasizes the cytomorphologic features and differential diagnosis of the most common CNS mesenchymal tumors (hemangioblastoma and solitary fibrous tumor/hemangiopericytoma) but also includes the cytomorphology of lipoma, rhabdomyosarcoma, Ewing sarcoma, fibrosarcoma, chordoma, and osteosarcoma involving the CNS.


Intraoperative brain assessment Cytology Squash preparation Smear preparation Non-meningothelial mesenchymal tumors Hemangioblastoma Solitary fibrous tumor Hemangiopericytoma Lipoma Lipomeningocele Leptomyelolipoma Spinal epidural lipoma Primary sarcomas of the brain Rhabdomyosarcoma Ewing sarcoma Chordoma Fibrosarcoma Osteosarcoma 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • César R. Lacruz
    • 1
  • Javier Saénz de Santamaría
    • 2
  • Ricardo H. Bardales
    • 3
  1. 1.Professor of PathologyComplutense University School of MedicineMadridSpain
  2. 2.Professor of PathologyUniversity Hospital Extremadura, Medical SchoolBadajozSpain
  3. 3.Pathologist, Director Ultrasound-guided Fine Needle Aspiration ServiceOutpatient Pathology Associates / Precision PathologySacramentoUSA

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