Optic Neuritis

  • Neil R. MillerEmail author


Optic neuritis may be caused by a variety of infectious, demyelinating, and inflammatory disorders. Following an attack of acute demyelinating optic neuritis (ON), there is a risk of developing multiple sclerosis (MS) especially if one or more periventricular demyelinating white-matter lesions is seen on magnetic resonance imaging (MRI) of the brain. Early treatment of MS with immunomodulatory drugs may helpful after ON. Other inflammatory demyelination syndromes such as neuromyelitis optica (NMO) and NMO spectrum disorder (NMOSD) or myelin oligodendrocyte glycoprotein (MOG) syndrome may mimic MS and can present with acute optic neuritis. In contrast to MS related ON however, bilateral, anterior, and/or recurrent ON is more likely to occur in NMO or MOG syndromes.


Neuromyelitis optica Myelin oligodendrocyte glycoprotein Optic neuritis 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Wilmer Eye Institute, Johns Hopkins HospitalBaltimoreUSA

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