• Roberta M. Leu


Supplemental melatonin is one of the most commonly recommended biomedical agents for difficulty falling asleep or maintaining sleep in children with neurodevelopmental disorders. This chapter provides an overview of melatonin, its synthesis, and its biological properties. Dosing of melatonin in sleep disorders, its pharmacokinetics, side effects, and potential drug interactions are discussed. Available data on the use of melatonin for sleep in specific neurodevelopmental populations including autism, attention-deficit/hyperactivity disorder, Angelman syndrome, Rett syndrome, fragile X syndrome, tuberous sclerosis, epilepsy, and traumatic brain injury is reviewed.


Melatonin Circadian rhythm Autism Attention-deficit/hyperactivity disorder Angelman syndrome Rett syndrome Fragile X syndrome Tuberous sclerosis Epilepsy Traumatic brain injury Insomnia Sleep problems 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Roberta M. Leu
    • 1
  1. 1.Pulmonary, Allergy/Immunology, Cystic Fibrosis and Sleep DivisionEmory University/Children’s Healthcare of AtlantaAtlantaUSA

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