Additional Substances to Glaucoma Medication: Preservative Free Treatment
Benzalkonium chloride (BAK) is one of the most popular preservatives, used in antiglaucomatous drugs. BAK mechanism of action is based on its’ ability to interfere with microorganisms’ cell membranes, causing lipid dispersion and lysis . BAK is highly lipophilic and acts as a detergent on the tear film.  Corneal cell membranes are also composed of phospholipid bilayer, which is susceptible to BAK .
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