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Myocardial Stunning

  • Dennis V. CokkinosEmail author
Chapter

Abstract

Myocardial stunning (STUN) is defined as the delayed recovery of systolic and diastolic cardiac function after reperfusion, despite restoration of normal flow. Its delayed reversibility implies that no irreversible cardiac damage has been caused. It is seen in many instances relevant to coronary artery disease, such as coronary angioplasty, angina pectoris, acute myocardial infarction, and exercise. It can be seen after cardiac surgery and tachycardia. More recently described situations are hemodialysis, sepsis, and the Takotsubo syndrome, i.e., cardiac dysfunction after severe mental stress. The cause of STUN is increased ROS production and calcium overload. Therapeutic aspects include the reversal of coronary artery stenosis and prevention or reversal of adrenergic activation.

Keywords

Stunning PTCA Angina pectoris Exercise myocardial infarction Takotsubo syndrome Hemodialysis 

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Heart and Vessel DepartmentBiomedical Research Foundation, Academy of Athens - Gregory SkalkeasAthensGreece

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