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Active Oxygen Defenses

  • Patrick L. Iversen
Chapter

Abstract

Metabolic defenses against environmental chemical exposures are essential. The cytochrome P450 family of mixed function oxidases play a prominent role transforming lipophilic threats into more water-soluble metabolites that are cleared from the body. The promiscuous heme active site also generates radical oxygen and nitrogen species capable of enhancing defense against infection but also may present a liability in tissue damage. The transcriptional regulation of metabolic enzymes is complex and coordinated with immune responses. In this way, the metabolic defenses parallel immune defenses as both can recognize and respond to a very large array of foreign chemicals and organisms. Metabolism provides resilience through transcriptional plasticity and metabolites drive downstream transcriptional changes essential for coordinated resilience.

Keywords

Reactive oxygen species Cytochrome P450 Genetic disease linkages NADPH cytochrome P450 reductase Transcriptome plasticity Nuclear receptors 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Patrick L. Iversen
    • 1
  1. 1.LS PharmaOregon State UniversityGrand JctUSA

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