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Fine-Tuning the Stem Cell Fate by Autophagy

  • Shalmoli Bhattacharyya
  • Ajay Kumar
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

A constant balance is required between the anabolic and catabolic process to maintain cellular homeostasis. The cellular processing of cytoplasmic components by autophagy is the major pathway for intracellular degradation and recycling. Autophagy plays an important role in maintaining cellular homeostasis and tissue remodeling during normal development. Basal level of autophagy is prevalent in most tissues and it adds to the normal turnover of cytoplasmic components in the cell. Autophagy is also associated with health and longevity of dividing and differentiated cells. Dysregulation of autophagic pathways have been linked with the pathogenesis of diseases like cancer and various neurodegenerative disorders. The stem cells are a unique population of cells in the body having a high longevity and differentiation ability; hence autophagy is predicted to play a crucial role in maintenance of cellular homeostasis of these cells. Extensive information elucidating the function of autophagy in somatic cells is available but in contrast, the implication of autophagy in maintenance as well as differentiation of stem cells is being revealed recently. In this chapter, we discuss the recent updates in our knowledge of stem cell differentiation, quiescence, and the role of autophagy in their regulation.

Abbreviations

AKT

Serine/threonine kinase 3

APL

Acute promyelocytic leukemia

ATG

Autophagy-related gene

bFGF

Basic fibroblast growth factor

BMMSC

Bone marrow-derived mesenchymal stem cells

CSC

Cancer stem cells

EGF

Epidermal growth factor

ESC

Embryonic stem cells

FIP200

FAK-family interacting protein 200

HGF

Hepatocyte growth factor

HSC

Hematopoietic stem cells

IBMX

Isobutyl methyl xanthine

LC3

Light chain 3

MAPK

Mitogen-activated protein kinase

OSM

Oncostatin M

PDGF

Platelet-derived growth factor

PI3

Phosphatidylinositol 3-kinase

PPAR

Peroxisome proliferator activator receptor

ROS

Reactive oxygen species

SC

Stem cell

STAT3

Signal transducer and activator of transcription

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Shalmoli Bhattacharyya
    • 1
  • Ajay Kumar
    • 1
  1. 1.Department of BiophysicsPGIMERChandigarhIndia

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