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Virus and Autophagy: Enemies or Allies

  • José A. Boga
  • Zulema Pérez-Martínez
  • Ana Coto-Montes
  • Marta E. Alvarez-Argüelles
  • Russel J. Reiter
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Viral infection is one of the several stimuli which trigger autophagy, a self-degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. This process also plays a housekeeping role in removing misfolded or aggregated proteins and clearing damaged organelles. Virus-induced autophagy has a dual role since it may be beneficial to the host by eliminating intracellular pathogens or it may benefit some viruses, which have developed strategies to directly or indirectly subvert autophagy in order to promote different stages of the viral life cycle. The upregulation of both oxidative and endoplasmic reticulum stresses has been reported as a means by which virus-induced pathways trigger autophagy. In this chapter the relationships between autophagy and viral infection are considered.

Keywords

Viral infection Autophagy 

Notes

Acknowledgments

Funding: This work was supported by project grants GRUPIN14-071 and GRUPIN14-099 from PCTI (Principado de Asturias) and FEDER funds (EU).

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • José A. Boga
    • 1
    • 2
  • Zulema Pérez-Martínez
    • 1
    • 2
  • Ana Coto-Montes
    • 3
    • 2
  • Marta E. Alvarez-Argüelles
    • 1
    • 2
  • Russel J. Reiter
    • 4
  1. 1.Servicio de MicrobiologíaHospital Universitario Central de AsturiasOviedoSpain
  2. 2.Instituto de Investigación Sanitaria del Principado de AsturiasISPAOviedoSpain
  3. 3.Departamento de Morfología y Biología Celular, Universidad de OviedoOviedoSpain
  4. 4.Department of Cellular & Structural BiologyUT Health Science Center at San AntonioSan AntonioUSA

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