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Autophagy and Stem Cells

  • Kai Li
  • Zhuo Yang
Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Autophagy, as a highly conserved cellular process, can achieve the degradation and recycling of intracellular substances, and is crucial for maintaining cellular homeostasis and remodeling of normal development. Dysfunctions in autophagy would cause a variety of illnesses including cancer, inflammatory bowel disease and neurodegenerative diseases. The unique self-renewal ability and differentiation ability of stem cells can improve these diseases. Therefore, exploring the mechanism of autophagy in maintaining stem cell homeostasis is crucial. Here we review the mechanisms and regulation of autophagy in embryonic stem cells, hematopoietic stem cells, mesenchymal stem cells, neural stem cells, and cancer stem cells. It helps us understand the relationship between autophagy and stem cells. Although there are many unanswered questions, the study of autophagy and stem cell biology can help us to progress in life sciences.

Keywords

Autophagy Stem cells Proliferation Differentiation Pluripotent 

Abbreviations

ASCs

Adult stem cells

ATG

Autophagy-related

BM-MSCs

Bone marrow MSCs

CMA

Chaperone-mediated autophagy

ESCs

Embryonic stem cells

HSCs

Hematopoietic stem cells

HSPCs

HSCs and progenitor cells

iPS

Induced pluripotent stem

LAMP2

Lysosomal-associated membrane protein 2

MSCs

Mesenchymal stem cells

NSCs

Neural stem cells

ROS

Reactive oxygen stress

SD-MSCs

Serum-deprived MSCs

SGZ

Subgranular zone

SVZ

Subventricular zone

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.College of Medicine, State Key Laboratory of Medicinal Chemical BiologyNankai UniversityTianjinChina

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