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Mesenchymal Stem Cell Based Approaches for Systemic Lupus Erythematosus Immunotherapy

  • Xuexiao JinEmail author
  • Shen Lu
  • Yang Yao
Chapter
Part of the Stem Cells in Clinical Applications book series (SCCA)

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by multi-organ involvement, with significant morbidity and mortality in young women predominantly. SLE is pathologically characterized by self-activation of auto-reactive immune responses, including activation of auto-reactive T cells and overproduction of autoantibodies by B cells. Although corticosteroids and immune-suppressants are widely used for the treatment, safer and more effective therapies are needed. The immunomodulatory properties and low immunogenic potential of mesenchymal stem cells (MSCs) make them a very promising new choice for treatment of severe refractory SLE. In this chapter, we provide a brief overview of MSCs treatment in SLE and describe current knowledge of the mechanisms by which they play parts in treating the disease, for better understanding of the pathogenesis and therapy for SLE.

Keywords

Mesenchymal stem cell Systemic lupus erythematosus Autoimmunity Immunotherapy Immunosuppression 

Abbreviations

APCs

Antigen-presenting cells

B7-H1

B7 homolog 1

BAFF

B cell activating factor

BM

Bone marrow

Bregs

Regulatory B cells

DCs

Dendritic cells

HGF

Hepatocyte growth factor

HSCs

Hematopoietic stem cells

IDO

Indoleamine-2-3-dioxygenase

IFN-γ

Interferon gamma

MMF

Mycophenolate mofetil

MSCs

Mesenchymal stem cells

NK cells

Natural killer cells

NO

Nitric oxide

NSAIDs

Non-steroidal anti-inflammatory drugs

PGE2

Prostaglandin E2

SLE

Systemic lupus erythematosus

SLEDAI

Systemic lupus erythematosus disease activity index

TGF-β

Transforming growth factor-β

TH cells

T helper cells

TNF-α

Tumor necrosis factor alpha

Tregs

Regulatory T cells

UC

Umbilical cord

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Institute of Immunology, Zhejiang University School of MedicineHangzhouChina
  2. 2.Zhejiang University–University of Edinburgh Institute, Zhejiang University School of MedicineHangzhouChina
  3. 3.Veritas Genetics Asia Inc.HangzhouChina

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