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Mesenchymal Stem Cells as Vectors for Cancer Therapy

  • Phuc Van PhamEmail author
  • Ngoc Bich Vu
Chapter
Part of the Stem Cells in Clinical Applications book series (SCCA)

Abstract

Mesenchymal stem cells (MSCs) are common stem cells in the human body. They have various properties and functions, including migration to tumors. Based on this property, MSCs have been used as vectors to deliver anti-cancer agents to tumors. To date, MSCs have been modified to express some factors or agents, including interleukin (IL)-12, IL-14, IFN-beta, IFN-gamma, TRAIL, and suicide genes/enzymes. Currently, MSCs are being modified to deliver oncolytic viruses and drug-loaded nanoparticles. In this chapter, updated information on the applications of engineered MSCs for cancer therapy will be discussed.

Keywords

Mesenchymal stem cell vector Cancer treatment Cell therapy for cancer Engineered stem cells Genetically modified stem cells 

Abbreviations

5-FU

5-fluorouracil

aaTSP-1

Protein thrombospondin

ALL

Acute lymphoblastic leukemia

bFGF

Basic fibroblast growth factor

EGF

Epidermal growth factor

EVs

Extracellular vesicles

EWS

Ewing sarcoma

GFP

Green fluorescent protein

HGF

Hepatic growth factor

hNSCs

Human neural stem cells

HSV-TK

Herpes simplex virus-1 thymidine kinase

HUVEC

Human umbilical cord vein endothelial cells

IFN-β

Interferon beta

IL

Interleukin

MIF

Migration inhibitory factor

MSCs

Mesenchymal stem cells

NDV

Newcastle disease virus

SDF

Stromal derived factor

UC

Umbilical cord

VEGF

Vascular endothelial growth factor

Notes

Acknowledgment

This study was supported by grant from the Ministry of Science and Technology via project No. DM.02.DA/15 “Assessment of the status, potential and capacity of research, application and development of stem cell technology in the field of medicine, pharmacy and agriculture.”

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Authors and Affiliations

  1. 1.Laboratory of Stem Cell Research and Application & Stem Cell Institute & Cancer Research LaboratoryVNUHCM University of ScienceHo Chi Minh CityVietnam
  2. 2.Laboratory of Stem Cell Research and Application & Stem Cell InstituteVNUHCM University of ScienceHo Chi Minh CityVietnam

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