Advertisement

Treatment of Irritability and Aggression in Huntington’s Disease

  • Karen E. Anderson
Chapter
Part of the Current Clinical Neurology book series (CCNEU)

Abstract

Irritability and aggression are common in Huntington’s disease (HD) and augment the burden faced by families caring for patients at home. Their presence can make placement in long-term care extremely difficult, since many facilities are not equipped to deal with severe behavioral symptoms, especially in relatively young patients who may be quite strong and therefore capable of harming themselves, facility staff, and other residents. Psychopharmacologic treatment of irritability and aggression can greatly reduce these symptoms in HD. Treatment involves a stepwise approach, depending on the level of symptom severity and urgency of the situation. This approach, based on HD, can also be used as a model for treatment of these symptoms in other neurological conditions.

Keywords

Huntington Irritability Aggression Perseveration 

Suggested Reading

  1. Anderson KE, Craufurd D, Edmondson MC, Goodman N, Groves M, van Duijn E, van Kammen DP, Goodman LV. An international survey-based algorithm for the pharmacologic treatment of obsessive-compulsive behaviors in Huntington’s disease. Version 1. PLoS Curr. 2011;3:RRN1261.  https://doi.org/10.1371/currents.RRN1261.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Bouwens JA, van Duijn E, van der Mast RC, Roos RA, Giltay EJ. Irritability in a prospective cohort of Huntington’s disease mutation carriers. J Neuropsychiatry Clin Neurosci. 2015;27(3):206–12.  https://doi.org/10.1176/appi.neuropsych.14030051. PMID: 26067436.CrossRefPubMedGoogle Scholar
  3. Chatterjee A, Anderson KE, Moskowitz CB, Hauser WA, Marder KS. A comparison of self-report and caregiver assessment of depression, apathy, and irritability in Huntington’s disease. J Neuropsychiatry Clin Neurosci. 2005;17(3):378–83. PMID: 16179661.CrossRefGoogle Scholar
  4. Groves M, van Duijn E, Anderson K, Craufurd D, Edmondson MC, Goodman N, van Kammen DP, Goodman LV. An international survey-based algorithm for the pharmacologic treatment of irritability in Huntington’s disease. Version 1. PLoS Curr. 2011;3:RRN1259. . Published online 2011 August 30.  https://doi.org/10.1371/currents.RRN1259.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Rosenblatt A, Leroi I. Neuropsychiatry of Huntington’s disease and other basal ganglia disorders. Psychosomatics. 2000;41(1):24–30.CrossRefGoogle Scholar
  6. van Duijn E, Craufurd D, Hubers AA, Giltay EJ, Bonelli R, Rickards H, Anderson KE, van Walsem MR, van der Mast RC, Orth M, Landwehrmeyer GB, European Huntington’s Disease Network Behavioural Phenotype Working Group. Neuropsychiatric symptoms in a European Huntington’s disease cohort (REGISTRY). J Neurol Neurosurg Psychiatry. 2014;85(12):1411–8.  https://doi.org/10.1136/jnnp-2013-307343. PMID: 24828898.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Karen E. Anderson
    • 1
  1. 1.Psychiatry & NeurologyGeorgetown MedStar Huntington Disease Care, Education and Research Center, a Huntington’s Disease Society of America Center of Excellence, Research Division, Department of PsychiatryWashington, DCUSA

Personalised recommendations