Red Blood Cell Biochemistry and Physiology

  • Eduard J. van Beers
  • Richard van WijkEmail author


This chapter examines the biochemistry and physiology of the red blood cells. It describes the development of the mature red blood cell through the process of hematopoiesis and the structure of hemoglobin. It also characterizes the structure and function of the red cell membrane and the various intracellular metabolic pathways. Both are of critical importance for red blood cell function and survival.


Red blood cell (RBC) Erythropoietin (EPO) Hemoglobin (Hb) Red blood cell cytoskeleton 2,3-diphosphoglycerate (2,3-DPG) Oxyhemoglobin dissociation curve Glycolysis Glutathione Embden-Meyerhof pathway Hexose monophosphate shunt Methemoglobin reduction pathway 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.University Medical Center Utrecht, Van CreveldkliniekUtrechtThe Netherlands
  2. 2.University Medical Center Utrecht, Department of Clinical Chemistry and HaematologyUtrechtThe Netherlands

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