Approach to the Bleeding Patient

  • Alvin H. Schmaier


This chapter aims to provide a simple diagnostic framework in which the physician can approach most patients with abnormal bleeding in a logical fashion to recognize the underlying cause. The diagnostic approach to bleeding disorders is based upon a full understanding of what the current screening assays for bleeding states measure.


Plasma protein defect Platelet abnormality Platelet-endothelial cell interactions Coagulation protein defects Prolonged bleeding time 

Suggested Reading

  1. Napolitano M, Schmaier AH, Kessler CM. Coagulation and fibrinolysis. In: McPherson P, editor. Henry’s clinical diagnosis and management by laboratory methods. 23rd ed. Philadelphia: Elsevier; 2017. p. 794–811.Google Scholar
  2. Schmaier AH. Laboratory evaluation of hemostatic and thrombotic disorders. In: Hoffman R, Benz EJ, Silberstein LE, Heslop H, Weitz JI, Anastasi J, editors. Hematology: basic principles and practice. 6th ed. Philadelphia: Elsevier; 2013. p. 1857–66.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of MedicineCase Western Reserve UniversityClevelandUSA
  2. 2.Department of MedicineUniversity Hospitals Cleveland Medical CenteryClevelandUSA

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