Thyroid Status and Outcomes in Kidney Disease

  • Connie M. RheeEmail author
  • Gregory A. Brent
  • Kamyar Kalantar-Zadeh


Thyroid dysfunction is a common yet under-recognized complication among chronic kidney disease (CKD) patients, including those with end-stage renal disease (ESRD) receiving treatment with dialysis [1, 2]. While comparatively greater focus has been placed upon other endocrine derangements in kidney disease, such as diabetes and secondary hyperparathyroidism, population-based studies have shown that advanced CKD and ESRD patients have a higher prevalence of hypothyroidism compared to the general population [3–10]. Despite this disproportionate burden, hypothyroidism may be frequently overlooked in dialysis patients, possibly due to overlap of its accompanying signs and symptoms with those of uremia (e.g., fatigue, depression, reduced cognition, impaired physical function), as well as attribution of thyroid function test changes to underlying illness rather than primary thyroid disease [1, 2].


Thyroid Hypothyroidism Hyperthyroidism Chronic kidney disease End-stage renal disease Dialysis Mortality Cardiovascular disease Health-related quality of life 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Connie M. Rhee
    • 1
    Email author
  • Gregory A. Brent
    • 2
  • Kamyar Kalantar-Zadeh
    • 3
  1. 1.Division of Nephrology and Hypertension, Departments of Medicine and Public Health, University of California Irvine School of MedicineOrangeUSA
  2. 2.Division of Endocrinology, Diabetes, and Hypertension, Departments of Medicine and PhysiologyDavid Geffen School of Medicine at UCLALos AngelesUSA
  3. 3.Division of Nephrology and Hypertension, Departments of Medicine, Pediatrics, Public Health, and Nursing Sciences, University of California Irvine School of MedicineOrangeUSA

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