Adiponectin and Leptin in Kidney Disease Patients

  • Jerry Zhong Yu
  • Kamyar Kalantar-Zadeh
  • Connie M. Rhee


Adiponectin is a type of adipokine, namely, a hormonally active molecule secreted by adipose tissue with pervasive effects on multiple organ systems. In the general population, adiponectin has demonstrated anti-inflammatory and cardioprotective properties, and a number of studies have shown that higher levels are associated with favorable cardiovascular outcomes and survival. However, in patients with non-dialysis-dependent (NDD) and dialysis-dependent chronic kidney disease (CKD), higher adiponectin levels have been paradoxically associated with adverse cardiovascular outcomes and higher mortality risk. Similarly, leptin is an adipokine which has been identified as having an important role in the regulation of inflammation and energy metabolism. In the general population, high serum leptin has been associated with adverse cardiovascular outcomes, but these observations are in contradistinction to findings observed in patients with end-stage renal disease (ESRD). The objective of this chapter is to review and discuss the existing body of evidence examining the interrelationships of adiponectin and leptin and outcomes in the general population as well as in those with varying degrees of impaired kidney function.


Adiponectin Leptin Adipokines Chronic kidney disease End-stage renal disease 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jerry Zhong Yu
    • 1
  • Kamyar Kalantar-Zadeh
    • 2
  • Connie M. Rhee
    • 3
  1. 1.Nephrology Associates Medical GroupRiversideUSA
  2. 2.Division of Nephrology and Hypertension, Departments of Medicine, Pediatrics, Public Health, and Nursing Sciences, University of California Irvine School of MedicineOrangeUSA
  3. 3.Division of Nephrology and Hypertension, Departments of Medicine and Public Health, University of California Irvine School of MedicineOrangeUSA

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