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Ocimum: The Holy Basil Against Cardiac Anomalies

  • Vishnu Sharma
  • Debabrata Chanda
Chapter
Part of the Compendium of Plant Genomes book series (CPG)

Abstract

Cardiovascular diseases have become a major health challenge in present time due to the change in lifestyle and industrialization leading to the higher morbidity and mortality. Diabetes, high blood pressure, physical inactivity, excessive weight, and consumption of alcohol and tobacco, and significant increase in life expectancy increased the frequency of cardiovascular diseases globally among all class and section of people. Cardiovascular diseases are clusters of different diseases including hypertension, coronary artery disease, angina, congestive heart disease, congenital heart disease, thrombosis, etc. Plants are being used as a remedy for various diseases since antiquity. The beneficial medicinal effects of these plant materials are mainly due to the chemical combinations of secondary metabolites produced by the plants. Ocimum (Tulsi), “Queen of herbs” has been regarded “elixir of life” and believed to promote longevity. The extract of Ocimum is being used in Ayurvedic remedies for common cold, headache, stomach disorder, inflammation, heart disease, malaria, etc. Ocimum has profound effect on treatment and prevention of cardiovascular diseases by means of lowering blood lipid content, suppressing ischemia and stroke, reducing hypertension, and also due to its higher antioxidant properties. Besides, it also plays an important role in antiplatelet aggregation and prevents risk of pulmonary hypertension. These cardioprotective properties prove that Ocimum may be treated as a good remedy against prevention and treatment of cardiovascular diseases.

Keywords

Ocimum Cardiovascular diseases Hypertension Antioxidant Congestive heart disease Pulmonary hypertension 

References

  1. Al Shukor N, Van Camp J, Gonzales GB, Staljanssens D, Struijs K, Zotti MJ (2013) Angiotensin-converting enzyme inhibitory effects by plant phenolic compounds: a study of structure activity relationships. J Agric Food Chem 61:11832–11839CrossRefGoogle Scholar
  2. Amrania S, Harnafib H, Gadib D, Mekhfib M, Legssyerb A, Azizb M, Martin-Nizardc FO, Bosca L (2009) Vasorelaxant and anti-platelet aggregation effects of aqueous Ocimum basilicum extract. J Ethnopharmacol 125:157–162CrossRefGoogle Scholar
  3. Anbarasu K, Vijayalakshmi G (2007) Improved shelf life of protein-rich tofu using Ocimum sanctum (Tulsi) extracts to benefit Indian rural population. J Food Sci 72:M300–M305CrossRefGoogle Scholar
  4. Auger C, Caporiccio B, Landrault N, Teissedre PL, Laurent C, Cros G, Besançon P, Rouanet JM (2002) Red wine phenolic compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters (Mesocricetus auratus). J Nutr 132(6):1207–1213CrossRefGoogle Scholar
  5. Biswas NP, Biswas AK (2005) Evaluation of some leaf dusts as grain protectant against rice weevil Sitophilus oryzae (Linn.). Environ Ecol 23:485–488Google Scholar
  6. Bogdan S, Seferian A, Totoescu A, Dumitrache-Rujinski S, Ceausu M, Coman C, Ardelean CM, Dorobantu M, Bogdan M (2012) Sildenafil reduces inflammation and prevents pulmonary arterial remodeling of the monocrotaline-induced disease in the wistar rats. Maedica 7:109–116PubMedPubMedCentralGoogle Scholar
  7. Bora KS, Shri R, Monga J (2011) Cerebroprotective effect of Ocimum gratissimum against focal ischemia and reperfusion-induced cerebral injury. Pharm Biol 49:175–181CrossRefGoogle Scholar
  8. Cardillo C, Kilcoyne CM, Quyyumi AA, Cannon RO III, Panza JA (1998) Selective defect in nitric oxide synthesismay explain the impaired endotheliumdependent vasodilatation in patients with essential hypertension. Circulation 97:851–856CrossRefGoogle Scholar
  9. Cassar K, Bachoo P, Brittenden J (2003) The role of platelets in peripheral vascular disease. Eur J Vasc Endovasc Surg 25:6–15CrossRefGoogle Scholar
  10. Chatterjee N, Agarwal S (1988) Liposomes as membrane model for study of lipid peroxidation. Free Radic Biol Med 4:51–72CrossRefGoogle Scholar
  11. Chen H, Yoshioka H, Kim GS, Jung JE, Okami N, Sakata H, Maier CM, Narasimhan P, Goeders CE, Chan PH (2011) Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid Redox Signal 14:1505–1517CrossRefGoogle Scholar
  12. Cheng CY, Su SY, Tang NY, Ho TY, Chiang SY, Hsieh CL (2008) Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats. Brain Res 13:136–150CrossRefGoogle Scholar
  13. Chopra RN, Nayer SI, Chopra IC (1956) Glossary of Indian medicinal plants. CSIR, New DelhiGoogle Scholar
  14. Croft KD (1998) The chemistry and biological effects of flavonoids and phenolic acids. Ann NY Acad Sci 854:435–442CrossRefGoogle Scholar
  15. Csiszar A, Labinskyy N, Olson S, Pinto JT, Gupte S, Wu JM, Hu F, Ballabh P, Podlutsky A, Losonczy G (2009) Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats. Hypertension 54:668–675CrossRefGoogle Scholar
  16. Daar AS, Singer PA, Persad DL, Pramming SK, Matthews DR, Beaglehole R, Bernstein A, Borysiewicz LK, Colagiuri S, Ganguly N, Glass RI (2007) Grand challenges in chronic non-communicable diseases. Nature 450(7169):494–496CrossRefGoogle Scholar
  17. Đorđević VB, Pavlović DD, Kocić GM (2000) Biohemija Slobodnih Radikala. Niš, Serbia, Medicinski Fakultet, pp 132–138Google Scholar
  18. Eriksson U, Danilczyk U, Penninger JM (2002) Just the beginning: novel functions for angiotensin-converting enzymes. Curr Biol 12:R745–R752CrossRefGoogle Scholar
  19. Fischer S, Weber PC (1984) Prostaglandin I3 is formed in vivo in man after dietary eicosapentaenoic acid. Nature 307:165–184CrossRefGoogle Scholar
  20. Ghouleh IA, Sahoo S, Meijles DN, Amaral JH, de Jesus DS, Sembrat J, Rojas M, Goncharov DA, Goncharova EA, Pagano PJ (2017) Endothelial Nox1 oxidase assembly inhuman pulmonary arterial hypertension; driver of gremlin1-mediated proliferation. Clin Sci 131:2019–2035CrossRefGoogle Scholar
  21. Gordon MC, David JN (2001) Naturan product drug discovery in the next millennium. Pharm Boil 39:8–17Google Scholar
  22. Grover-Paez F, Zavalza-Gomez AB (2009) Endothelial dysfunction and cardiovascular risk factors. Diabetes Res Clin Pract 84:1–10CrossRefGoogle Scholar
  23. Guilbert JJ (2003) The World health report 2002 - reducing risks, promoting healthy life. Educ Health 16(2): 230 (Abingdon, England)Google Scholar
  24. Gupta SK, Prakash J, Srivastav S (2002) Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. Indian J Exp Biol 40:765–773PubMedGoogle Scholar
  25. Gupta S, Mediratta PK, Singh S, Sharma KK, Shukla R (2006) Antidiabetic, antihypocholestrolaemic and antioxidant effect of Ocimum sanctum (Linn) seed oil. Indian J Exp Biol 44:300–304PubMedGoogle Scholar
  26. Hakkim FL, Arivazhagan G, Boopathy R (2008) Antioxidant property of selected Ocimum species and their secondary metabolite content. J Med Plants Res 2:250–257Google Scholar
  27. Husain R, Cilliard J, Cilliard P (1987) Hydroxyl radical scavenging activity of flavonoids. Phytochemistry 26:2489–2491CrossRefGoogle Scholar
  28. Imlay JA, Linn S (1988) DNA damage and oxygen radical toxicity. Science 240:1302–1309CrossRefGoogle Scholar
  29. Interaminense LF, Leal-Cardoso JH, Magalhães PJ, Duarte GP, Lahlou S (2005) Enhanced hypotensive effects of the essential oil of Ocimum gratissimum leaves and its main constituent, eugenol, DOCA-salt hypertensive conscious rats. Planta Med 71(4):376–378CrossRefGoogle Scholar
  30. Irondi EA, Agboola SO, Oboh G, Boligon AA (2016) Inhibitory effect of leaves extracts of Ocimum basilicum and Ocimum gratissimum on two key enzymes involved in obesity and hypertension in vitro. J Intercult Ethnopharmacol 5(4):396–402CrossRefGoogle Scholar
  31. Jaggi RK, Madaan R, Singh B (2003) Anticonvulsant potential of holy basil, Ocimum sanctum Linn., and its cultures. Indian J Exp Biol 41:1329–1333PubMedGoogle Scholar
  32. Jeffery TK, Wanstall JC (2001) Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension. Pharmacol Ther 92:1–20CrossRefGoogle Scholar
  33. Kelm MA, Nair MG, Strasburg GM, DeWitt DL (2000) Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine 7:7–13CrossRefGoogle Scholar
  34. Kelsey NA, Wilkins HM, Linseman DA (2010) Nutraceutical antioxidants as novel neuroprotective agents. Molecules 15:7792–7814CrossRefGoogle Scholar
  35. Korsholm K, Andersen A, Kirkfeldt RE, Hansen KN, Mellemkjær S, Nielsen-Kudsk JE (2015) Survival in an incident cohort of patients with pulmonary arterial hypertension in Denmark. Pulm Circ 5:364–369CrossRefGoogle Scholar
  36. La Rosa JC, Hunninghake D, Bush D (1990) The cholesterol fact: a summary of the evidence relating dietary fats, serum cholesterol and CHD. A joint statement by the American Heart Association and the National Heart, Lung and Blood Institute. Circulation 81:1721–1733CrossRefGoogle Scholar
  37. Lee TH, Hoover RL, Williams JD, Sperling RI, Ravalese JR III, Spur BW, Robinson DR, Corey EJ, Lewis RA, Austen KF (1985) Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leucotriene generation and neutrophil function. New England J Med 312:1217–1224CrossRefGoogle Scholar
  38. Lee BH, Lai YS, Wu SC (2015) Antioxidation, angiotensin converting enzyme inhibition activity, nattokinase, and antihypertension of Bacillus subtilis (natto)-fermented pigeon pea. J Food Drug Anal 1:1–8Google Scholar
  39. Liu J, Simon LM, Philips JR, Robin ED (1977) Superoxide dismutase (SOD) activity in hypoxic mammalian systems. J Appl Physiol 42:107–110CrossRefGoogle Scholar
  40. Loscalzo J, Welch G (1995) Nitric oxide and its role in the cardiovascular system. Prog Cardiovasc Dis 38:87–104CrossRefGoogle Scholar
  41. Manea SA, Constantin A, Manda G, Sasson S, Manea A (2015) Regulation of Nox enzymes expression in vascular pathophysiology: focusing on transcription factors and epigenetic mechanisms. Redox Biol 5:358–366CrossRefGoogle Scholar
  42. Margaill I, Plotkine M, Lerouet D (2005) Antioxidant strategies in the treatment of stroke. Free Radic Biol Med 39:429–443CrossRefGoogle Scholar
  43. McLaughlin VV, Davis M, Cornwell W (2011) Pulmonary arterial hypertension. Curr Probl Cardiol 36:461–517CrossRefGoogle Scholar
  44. Meghwani H, Prabhakar P, Mohammed SA, Seth S, Hote MP, Banerjee SK, Arava S, Ray R, Maulik SK (2017) Beneficial effects of aqueous extract of stem bark of Terminalia arjuna (Roxb.), An ayurvedic drug in experimental pulmonary hypertension. J Ethnopharmacol 197:184–194CrossRefGoogle Scholar
  45. Meghwani H, Prabhakar P, Mohammed SA, Dua P, Seth S, Hote MP, Banerjee SK, Arava S, Ray R, Maulik SK (2018) Beneficial effect of Ocimum sanctum (Linn) against monocrotaline-induced pulmonary hypertension in rats. Medicines 5(34):1–15Google Scholar
  46. Mekhfi H, ElHaouari M, Bnouham M, Aziz M, Ziyyat A, Legssyer A (2006) Effects of extracts and tannins from Arbutus unedo leaves on rat platelet aggregation. Phytother Res 20:135–139CrossRefGoogle Scholar
  47. Murphy KJ, Chronopoulos AK, Singh I, Francis MA, Moriarty H, Pike MJ, Turner AH, Mann NJ, Sinclair AJ (2003) Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. Am J Clin Nutr 77:1466–1473CrossRefGoogle Scholar
  48. Narkiewicz K (2006) Obesity and hypertension - the issue is more complex than we thought. Nephrol Dial Transplant 21:264–267CrossRefGoogle Scholar
  49. National Cholesterol Education Program (NCEP III) (2002) Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (adult treatment panel III) final report 2002. Circulation 106(25):3143–3421CrossRefGoogle Scholar
  50. Nelson F, Nyarko KM, Binka FN (2015) Prevalence of risk factors for non-communicable diseases for new patients reporting to Korle-Bu Teaching Hospital. Ghana Med J 49(1):12–18CrossRefGoogle Scholar
  51. Nour M, Scalzo F, Liebeskind DS (2013) Ischemia-reperfusion injury in stroke. Interv Neurol 1:185–199CrossRefGoogle Scholar
  52. Oboh G, Ademiluyi AO, Akinyemi AJ, Henle T, Saliu JA, Schwarzenbolz U (2012) Inhibitory effect of polyphenol-rich extracts of Jute leaf (Corchorus olitorius) on key enzyme linked to type-2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting) in vitro. J Funct Food 4:450–458CrossRefGoogle Scholar
  53. Robak J, Gryglewski J (1988) Flavonoids are scavengers of superoxide anion. Biochem Pharmacol 37:837–841CrossRefGoogle Scholar
  54. Rodrigo E, Maeso R, Muanoz-Garcaia R (1997) Endothelial dysfunction in spontaneously hypertensive rats: consequences of chronic treatment with losartan or captopril. J Hypertens 15:613–618CrossRefGoogle Scholar
  55. Saggini A, Anogeianaki A, Angelucci D, Cianchetti E, D’Alessandro M, Maccauro G, Salini V, Caraffa A, Teté S, Conti F, Tripodi D, Fulcheri M, Frydas S, Shaik-Dasthagirisaheb YB (2011) Cholesterol and vitamins: revisited study. J Biol Regul Homeost Agents 25(4):505–515PubMedGoogle Scholar
  56. Sen P (1993) Therapeutic potential of Tulsi: from experience to facts. Drug News Views 1:15–21Google Scholar
  57. Sharma AM (2004) Is there a rationale for angiotensin blockade in the management of obesity hypertension? Hypertension 44:12–19CrossRefGoogle Scholar
  58. Shishodia S, Majumdar S, Banerjee S, Aggarwal BB (2003) Urosolic acid inhibits nuclear factor-kappa B activation induced by carcinogenic agents through suppression of I kappa B alpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res 63:4375–4383PubMedGoogle Scholar
  59. Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Krishna Kumar R, Landzberg M, Machado RF (2013) Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 62:D34–D41CrossRefGoogle Scholar
  60. Suanarunsawat T, Ayutthaya WDN, Songsak T, Thirawarapan S, Poungshompoo S (2011) Lipid-lowering and antioxidative activities of aqueous extracts of Ocimum sanctum L. leaves in rats fed with a high-cholesterol diet. Oxid Med Cell Longev.  https://doi.org/10.1155/2011/962025CrossRefPubMedPubMedCentralGoogle Scholar
  61. Surapaneni S, Prakash T, Ansari M, Manjunath P, Kotresha D, Goli D (2016) Study on cerebroprotective actions of Clerodendron glandulosum leaves extract against long term bilateral common carotid artery occlusion in rats. Biomed Pharmacother 80:87–94CrossRefGoogle Scholar
  62. Talayero BG, Sacks FM (2011) The role of triglycerides in atherosclerosis. Curr Cardiol Rep 13(6):544–552CrossRefGoogle Scholar
  63. Tofler GH, Muller JE (2006) Triggering of acute cardiovascular disease and potential preventive strategies. Circulation 114(17):1863–1872CrossRefGoogle Scholar
  64. Tohti I, Tursun M, Umar A, Subat T, Imin H, Moore N (2006) Aqueous extracts of Ocimum basilicum L (sweet basil) decrease platelet aggregation induced by ADP and thrombin in vitro and rats arterio-venous shunt thrombosis in vivo. Thromb Research 118:733–739CrossRefGoogle Scholar
  65. Uma Devi P, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK (2000) Radiation protection by the Ocimum flavonoids orientin and vicenin: Mechanisms of action. Radiat Res 154:455–460CrossRefGoogle Scholar
  66. Umar A, Imam G, Yimin W, Kerim P, Tohti I, Berké B, Moore N (2010) Antihypertensive effects of Ocimum basilicum L. (OBL) on blood pressure in renovascular hypertensive rats. Hypertens Res 33(7):727–730CrossRefGoogle Scholar
  67. Verma S, Bhanot S, Yao L, McNeill J (1996) Defective endothelium-dependent relaxation in fructose-hypertensive rats. Am J Hypertens 9:370–376CrossRefGoogle Scholar
  68. Villiger A, Sala F, Suter A, Butterweck V (2015) In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome. Phytomedicine 22:138–144CrossRefGoogle Scholar
  69. Warner DS, Sheng H, Batinić-Haberle I (2004) Oxidants, antioxidants and the ischemic brain. J Exp Biol 207:3221–3231CrossRefGoogle Scholar
  70. Warrier PK (1995) In: Longman O (ed) Indian medicinal plants. CBS publication, New Delhi, p 168Google Scholar
  71. Wink M (2000) Introduction biochemistry, role and biotechnology of secondary products. In: Wink M (ed) Biochemistry of secondary product metabolism. CRC press, Boca Raton, Florida, pp 1–16Google Scholar
  72. World Health Organization (2015) Cardiovascular diseases (CVDs), http://www.who.int/mediacentre/factsheets/fs317/en/
  73. Yokozawa T, Cho EJ, Sasaki S, Satoh A, Okamoto T, Sei Y (2006) The protective role of Chinese prescription Kangenkaryu extract on diet-induced hypercholesterolemia in rats. Biol Pharmaceut Bull 29(4):760–765CrossRefGoogle Scholar
  74. Zurier B (1991) Essential fatty acids and inflammation. Ann Rheumat Dis 50(11):745–746CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.In Vivo Testing Facility, Molecular Bioprospection Department, Biotechnology DivisionCSIR-CIMAPLucknowIndia

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